Sickle-Cell Disease

Sickle cell disease is an example of codominance, not heterozygous dominance. In individuals who are heterozygous for the sickle cell allele, they exhibit a milder form of the disease called sickle cell trait, which demonstrates codominance of the normal and mutant hemoglobin alleles.

Individuals with two recessive alleles have very high rates of reproduction.

One pleiotropic effect of sickle cell syndrome is increased resistance to malaria. The genetic mutation that causes sickle cell disease also confers some protection against malaria infection, as the malaria parasite has difficulty surviving in the altered red blood cells of individuals with sickle cell trait.

they have one normal hemoglobin gene that can produce functional hemoglobin to carry oxygen effectively, compensating for the abnormal hemoglobin produced by the gene for sickle cell disease. This keeps their red blood cells from sickling and causing blockages in blood vessels that lead to symptoms of the disease.

The dangerous mutation in sickle cell anemia is a point mutation in the HBB gene that results in the substitution of glutamic acid with valine in the beta-globin chain of hemoglobin. This leads to the production of abnormal hemoglobin known as hemoglobin S, which causes red blood cells to take on a sickle shape, leading to various complications such as vaso-occlusive crises, anemia, and organ damage.

In a nutshell, it makes your RBCs (Red Blood cells) sickle shaped. The RBCs can't pick up as much oxygen so you may have trouble breathing. They also collect around the joints causing extreme pain.

Since you did not specify what parental cross you wished to represent this is the best I can do for you. A "normal" male would be represented as XHYo - gametes XH and Yo A male with hemophilia would be represented as XhYo - gametes Xh and Yo A female non-carrier would be represented as XHXH - gametes XH A female carrier would be represented as XHXh - gametes XH and Xh A female with hemophila would be represented as XhXh - gametes Xh

For starters, its immune. Second, sickle cells makes one resistant to malaria if in the heterozygous form (one normal blood cell and one sickle cell allele) but if found in the homozygous form (both alleles for sickle cells) the result is misshapen blood cells that to don't carry enough oxygen through the blood to keep a person alive usually resulting in death.

Sickle-cell anemia is characterised by abnormal haemoglobin which are not the correct shape and cannot carry oxygen.

It is a genetic disease - and a person must have two copies of the gene to have sickle-cell anemia. (Heterozygous individuals, with one copy, are known as having sickle-cell trait - and some of their haemoglobin may be misshapen).

In Africa, malaria is a common disease. It attacks healthy blood cells and uses them to travel throughout the body. However, if one has sickle-shaped blood cells, this makes it harder for the malaria to attach and travel through the body.

Yes, individuals with sickle cell anemia can live into adulthood with proper care and management of the condition. Regular medical check-ups, adherence to prescribed treatment plans, and healthy lifestyle choices can help improve quality of life and overall life expectancy for those with sickle cell anemia.

Sickle cell disease is an inherited genetic disorder caused by having two copies of the sickle cell gene. When both parents are carriers of the gene, each child has a 25% chance of inheriting the disease. Not every generation will have the disease because it depends on whether the gene is passed down from both parents.

sickle cell trait is inherited from one set of gene alleles from both parents. if you get two traits together it will cause sickle cell anemia which is a disease, sickle cell trait is not a disease.

i dont know what autosomal means!!

i dont know what codominance means!!

If both U and her husband are carriers of the sickle cell trait, there is a 25% chance that their child will develop sickle cell disease. This is because there is a 50% chance the child will inherit one sickle cell gene from each parent, resulting in the disease.

Yes, sickle-cell anemia is a genetic disorder that affects hemoglobin, causing red blood cells to become rigid and sickle-shaped under certain conditions. This sickling process can lead to blockages in blood vessels, resulting in pain, damage to organs, and other complications.

Sickle cell anemia is caused by a point mutation in the HBB gene, specifically a substitution of adenine for thymine in the sixth codon of the gene, resulting in the production of abnormal hemoglobin known as hemoglobin S.

Sickle cell disease is a genetic disorder that affects the red blood cells. It is caused by a mutation in the gene that affects the production of hemoglobin, a protein in red blood cells that helps carry oxygen throughout the body.

People who are heterozygous for sickle cell disease possess one normal hemoglobin gene and one sickle hemoglobin gene, which allows them to produce enough normal red blood cells to prevent symptoms of the disease. This condition, known as sickle cell trait, provides some protection against malaria, as the presence of sickle hemoglobin can interfere with the parasite's life cycle within red blood cells.

Sickle cell anemia can lead to mental health challenges such as depression, anxiety, and cognitive impairment due to complications like chronic pain, organ damage, and reduced blood flow to the brain. These factors can impact a person's overall quality of life, ability to concentrate, memory, and decision-making skills. It is important for individuals with sickle cell anemia to receive comprehensive care that includes mental health support.

No, Tiki Barber does not have sickle cell disease. He is a retired NFL player who has been very active in various charitable causes, but sickle cell disease is not one of the health conditions he has publicly discussed.

It's not sickle-cell itself, but rather being a heterozygous carrier of the disease. People with one dominant and one recessive allele for the disease are immune to malaria without the crippling effects of having sickle-cell anemia. I don't think that it can even represent codominance, though.

Yes there is a connection , those who suffer from sickle cell anemia, nicotine makes it a worse condition.

nicotine cause blood vessels to contract more which cause increased pain, and causes reduced oxygen to the lungs.

Those with sickle cell is anemic and nicotine further deletes the supply of oxygen to the body.

I know a person who did not wanted to quit smoking and he had sickle cell diseases. He was taking medication but it did not help because of nicotine, so he passed away earlier than expected.

Sickle cells belong to the poikilocyte category of red blood cell morphology, characterized by abnormal shape or deformity.

Yes, an adult can be diagnosed with sickle cell anemia. The condition is usually detected in childhood through newborn screening or during genetic testing later in life. Adults who have not been previously diagnosed may present with symptoms such as anemia, pain crises, or complications related to sickle cell disease.

The inherited blood disorder that causes mild or severe anemia due to reduced hemoglobin and fewer red blood cells than normal is called thalassemia. Thalassemia is a genetic condition that affects the production of hemoglobin, the protein in red blood cells that carries oxygen throughout the body. Treatment options for thalassemia may include blood transfusions, medication, and in some cases, bone marrow transplants.