Sickle-Cell Disease

Hemoglobin is a protein, which is composed of linked amino acids.

G6PDD does not protect against malaria infection. People with G6PD Deficiency can still get it like anyone else. The malaria larva has to have mature red blood cells to live in and cannot survive in immature ones. An rbc's normal life span is 120 days, but due to hemolysis, many do not live this long. The faster death of rbc's also causes the malaria larva to die as well. There are two problems with this. The first is obvious as hemolysis (death of rbcs) also causes us problems. Although G6PD Deficient people are spared the severe symptoms of malaria, they have to weather hemolysis and must rely on their ability to make new rbcs. The infection is still sequestered in their liver. The second is that there is no anti-malarial medication that is friendly to G6PD Deficient people.

Malaria is dangerous and precautions should be taken to avoid infection. Anti-malarials are not an option. You can learn more about this at g6pddeficiency.org.

It is evident as soon as you are born if you have it.

Most of them I would imagine.

It affects those who are carriers as well as those who have the disease fully. Carriers though have both sickle cell blood cells and normal ones, and therefore can usually function just like other people would.

It is most often seen in African-Americans.

Mutations in the hemoglobin molecules cause sickle cell anemia.

No they are generally resistant to malaria

yes there are two concentrations of sickle cell

they are:

sickle cell trait: co-dominance is established and only 50% of your cells are malformed

sickle cell anemia: sickle cell is totally dominant and all cells are malformed, this only happens when both alleles are coded for sickle cell

A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.

Sickle Cell Disease is a blood disorder that is permanent. It is a lifelong struggle for those who have it. Those suffering from the disease need to take a variety of medications in order to maintain their health and survive.

Yes, but the mutation happened many many thousands of years ago. It has been passed on through all these generations because the same gene that causes sickle cell anemia in a person that inherits two copies of the gene also causes resistance to the malaria parasite in a person that inherits only one copy of the gene.

In areas of the world where malaria is a common disease, the resistance to it is a stronger selective advantage than sickle cell anemia is a selective disadvantage; so the gene becomes very common in those populations.

lol that's a dumb question

and that's a dumb answer. Yes it is always possible, to some tiny degree. The risk factor is dependent on the specific races involved. For example a person of African decent has a higher risk, than a person of hispanic or Mediterranean, and caucasian is the lowest risk of all. If one parent is caucasian the risk is pretty small. among 2 caucasians, not of middle eastern or Mediterranean, non jewish, the risk is smallest.

It is when your body does not produce alot of blood and you become very skinny and sick. It can be passed on to babies by mothers and mostly occurs in African countries and some parts of Asia, too.

That is very interesting question, indeed. Your concern for the primates needs appreciation. The answer to this question is probably positive. Sickle cell anaemia is a natural selection in malaria endemic zone. The sickle cell trait patient is genetically resistant to malarial fever. So many primates suffer from malarial fever. From this finding you can say that sickle cell anaemia should be present in primates, who live in tropical countries.

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They are both genetic blood disorders, which are inherited from the parents.

Sickle cell anemia is caused by a mutation in the gene responsible for hemoglobin. If a person has inherited the mutation, their bone marrow will produce sticky, sickle-shaped red blood cells, which cause a wide array of issues.

Hemophilia is another blood disorder that is inherited from the parents, but in a different and more complicated way. Hemophiliacs (people suffering from hemophilia) have a problem with blood clotting. They will always bruise easily, and when they bleed, the blood might not clot unless certain actions are taken.

Both diseases affect the blood, and are life long. There are currently no effective cures for them.

My brother had iron-deficiency anemia as a kid and he had to take pills to help raise his iron-levels. There are also iron-filled foods that can raise the level naturally, including beans and spinach. (It wasn't Popeye's source of strength for no reason.)

The parents are both recessive (Ss) for sickle cell anemia.

Because the spleen is responsible for destruction of abnormal red blood cells; therefore since sickle cell causes abnormalities in red blood cells, the spleen works extra hard for extended periods of time to remove them.

Sickle cell trait carries a lower risk of serious malarial disease, without the signs and symptoms of sickle-cell anemia.

Sickle cell appears in several geographical regions in the world and is attached to different genes in those areas. It appears where malaria is endemic. The African form is the most common. Different forms developed in Southern Greece, Southern Afghanistan, and a few other places. The African form affects Black people.

Sickele-Cell Anemia ia one one of the most common genetic blood disorders.

7-12 µm in diameter in humans