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Sickle-Cell Disease
Sickle-cell disease is a genetic blood disorder wherein the red blood cells are irregularly shaped due to the blood’s lowered oxygen tension. This irregularity may result in chronic anemia, serious infections, painful conditions, damage to organs and death.
538 Questions
A single sickle-cell gene protects against malaria. Two sickle-cell genes produce sickle-cell disease.
Is sickle-cell disease a result of a translocation?
No. It arises due to point mutations (like A -> T).
Do you have to be born with sickle cell anemia?
If you were not born with this condition then you will not develop it during your life.
The condition is generally inherited as it is a genetic mutation. However, it is possible that the mutation could spontaneously happen in any baby.
The reason why this (sometimes fatal) condition has persisted in certain African populations is because it imparts a resistance to malaria.
If malaria were eliminated how might the frequency of the sickle-cell allele change over time?
Since people with the sickle cell allele trait are resistent to malaria, if malaria were eliminated there would be no change in the frequncy of sickle cell allele. This is because the presense of malaria does not have an affect on patients with the sickle cell allele trait.
How do you type the hammer and sickle symbol?
To type the hammer and sickle symbol (☭), you can use the Unicode character by entering "U+262D" in a compatible application, or by using a character map tool to copy and paste it. On Windows, you can also type it by holding down the "Alt" key and entering "9763" on the numeric keypad. For Mac users, you can use the Character Viewer by searching for "hammer and sickle."
What is the compared shape of a red blood cell to that of a sickle cell?
The red blood cells have a sickle shape, hence the name. They receive this shape from a protein in normal blood cells that is mutated. They carry less blood and block veins and capillaries easily.
What are the Current trends and issues of maternal child health nursing in the Philippines?
The latest health trends and issues in the Philippines is average with ever 2 per 100 people suffering from major chronic diseases. The healthcare system is not good due to the state of the economy of the country.
When do the symptoms of sickle cell anemia appear?
If you have sickle cell anemia and already know it, then it wil lbe pretty easy to tel lwhen the symptoms show themselves. I don't have it myself but people with sickle cell apparently go through a lot of pain when a sickle cell gets stuck in a blood vessel and causes a clot; there isn't a cure, just doctors can give stuff to make the pain less but not totally go awayunless maybe they knock you unconscious. Also people with sickle cell have more trouble with sports and activites since sickle cells can't carry as much oxygen as normal ones. I'm sorry, but that's all the symptoms I know...
What does Hammer and sickle mean?
They were used by the Supreme Soviet as a reflection of the proletarian ideology they supposedly adhered to (although not so much in practice). Marx believed that the workers (represented by the tools they used - the hammer and sickle) would one day rise up and seize the means of production, and from this would gain control and create a worldwide single Communist state.
The mutant allele causing sickle-cell anemia is found at high frequency mainly due to?
Sickle cell anemia is found in high frequency because it is a codominant mutation. It only requires one allele for the gene to manifest.
Why are people with sickle cell trait resistant to malaria?
Not sure if this is right but could it be because the blood cell does not contain enough oxygen for the parasite to survive?
Why do sickle cell anemia cause so many problems?
A sickle cell is a malformed red blood cell. It is caused by a mutated gene inherited from one or both parents. If inherited from both parents the red cells are very malformed, causing sickle-cell anaemia. This is a serious illness, causing weakness and shortness of breath and often leading to an early death.
Mutations like this are usually steadily removed from the gene pool because those with it tend to have fewer children. The sickle-cell gene remains in the gene pool because those who get it from only one parent have a slightly deformed red-cell. This causes only limited problems for the bearer, and has one large advantage - it makes the red-cell taste nasty to the malaria parasite. In other words, it protects against malaria which is otherwise often fatal.
In areas where malaria is endemic it is common to find the sickle cell gene in about 15% of the population. When Africans came to the USA as slaves the gene came with them. However, malaria has never been common in the US, and the percentage of sickle-cell gene in black Americans has decreased steadily.
What is the relation of amino acid to sickle cell hemoglobin?
Hemoglobin is a protein, which is composed of linked amino acids.
What is the relationship between sickle-cell disease and malaria?
G6PDD does not protect against malaria infection. People with G6PD Deficiency can still get it like anyone else. The malaria larva has to have mature red blood cells to live in and cannot survive in immature ones. An rbc's normal life span is 120 days, but due to hemolysis, many do not live this long. The faster death of rbc's also causes the malaria larva to die as well. There are two problems with this. The first is obvious as hemolysis (death of rbcs) also causes us problems. Although G6PD Deficient people are spared the severe symptoms of malaria, they have to weather hemolysis and must rely on their ability to make new rbcs. The infection is still sequestered in their liver. The second is that there is no anti-malarial medication that is friendly to G6PD Deficient people.
Malaria is dangerous and precautions should be taken to avoid infection. Anti-malarials are not an option. You can learn more about this at g6pddeficiency.org.
Does sickle cell appear at birth or later on in life?
It is evident as soon as you are born if you have it.
Does sickle cell anemia affect certain groups of people more than others?
It affects those who are carriers as well as those who have the disease fully. Carriers though have both sickle cell blood cells and normal ones, and therefore can usually function just like other people would.
It is most often seen in African-Americans.
What type of mutation cause cell anemia?
Mutations in the hemoglobin molecules cause sickle cell anemia.
yes there are two concentrations of sickle cell
they are:
sickle cell trait: co-dominance is established and only 50% of your cells are malformed
sickle cell anemia: sickle cell is totally dominant and all cells are malformed, this only happens when both alleles are coded for sickle cell
What Diseases are caused by lack of sunshine?
The many health benefits of sunlight are discussed, such as relief from depression, improved digestion and an increase in your metabolism.
Also, Vitamin D is the nutrient received from sunlight.
Active vitamin D is a potent immune system modulator. There is plenty of scientific evidence that vitamin D has several different effects on immune system function that may enhance your immunity and inhibit the development of autoimmunity.
It also maintains your calcium balance.
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
