Sickle-Cell Disease

Sickle cell anemia is a genetic blood disorder affecting individuals who inherit two copies of the abnormal hemoglobin gene from both parents. This primarily affects people of African, Mediterranean, Middle Eastern, and South Asian descent.

Sickle cell disease is caused by a mutation in the gene that encodes for hemoglobin, a protein in red blood cells that carries oxygen. This mutation results in the production of abnormal hemoglobin known as hemoglobin S, which causes red blood cells to become sickle-shaped and less flexible.

Sickle cell anemia is a recessive genetic disorder caused by a mutation in the HBB gene, located on chromosome 11. It is inherited in an autosomal recessive pattern, meaning a person needs to inherit two abnormal copies of the gene (one from each parent) to have the disease. It is not an X-linked disorder or a multifactoial trait.

If you are heterozygous this means you carry both a dominant and recessive allele. if you are heterozygous for a recessive trait then you will have a dominant and recessive allele. example: let T represent tall and t represent short. a person with heterozygous for a recessive trait will have 'Tt'.

Some diseases are the result of adaptations to an environment. As it turns out, Sickle Cell Anemia is an adaptation to Malaria. If a person has a single copy of the Sicke Cell gene, he or she is protected against Malaria. If he or she has NO copies of the gene, he or she will die if exposed to Malaria. If he or she has two copies of the gene he or she will die from Sickle Cell Anemia. Malaria was fatal to pretty much everyone. The genetic mutation allowed about half of the population of the region to live. Today, we no longer have the threat from Malaria so now Sickle Cell Anemia becomes the problem.

Approximately 100,000 people die each year from complications of sickle cell disease, with most deaths occurring in sub-Saharan Africa. Early detection, proper management, and access to healthcare can help improve outcomes for individuals with sickle cell disease.

yes

An example of point-mutation is sickle-cell anemia. Sickle-cell disease is hereditary.

Peope with sickle cell disease suffer from pain crisis in arms,legs or ,chest. Well at least my daughter do. It is painful and she has to be admitted to hospital and receive morphine and. Iv fluids to relieve pain.

once youdidn't get it from birth, then it is not possible to get it when you grown up, but if you want to protect your future children not get the disease than it is better not to married from sickle cell disease man

It is impossible to predict what will happen with one person!

In a population of 2,000 people, 1,000 women have sickle cell trait and 1,000 men do not. They marry. Each couple has 2 children. 1,000 children will have sickle cell trait and 1,000 children will not.

In a population of 2,000 people, 1,000 women have sickle cell trait and 1,000 men have sickle cell trait. They marry. Each couple has 2 children. 1,000 children will have sickle cell trait, 500 children will not, and 500 children will have sickle cell anemia.

No one knows which of those parents will produce which children. No one knows how to predict how your children will turn out.

Yes

Exercising cost lot of energy.So Oxygen requirement increase.People with sickle cells, do not have normal number of blood cells to carry Oxygen.So energy production would not be sufficient.

People who have sickle cell should try to avoid consuming alcohol if at all possible. This is because sickle cell causes the patient to become dehydrated in the first place, so drinking alcohol would only exacerbate the problem.

Sickle cell anemia is an autosomal recessive disorder. It can result from two carriers having a child together.

underwear

Red Blood Cells. It is called

sickle cell because some of the red blood cells

are long and shaped like sickles. Although sickle

cell disease primarily affects African Americans,

it is also found in Hispanics, Italians, Greeks and

people of Mediterranean descent.

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no it dose not sickle cell anemia causes death only if African Americans

infection

No, tattoos will not effect the disease. Just be sure to take your regular antibiotics if needed to prevent any infections.

It is a genetic disorder.

However...

It is also a protection against malaria.

For example, if a person were born in an area where malaria is present, he or she would likely die from the disease, unless he or she inherited 1 sickle cell gene.

Malaria viruses reproduce in the red blood cells. The parent virus invades a cell, and uses the cell as a host to grow more viruses.

With 1 sickle cell gene, malaria viruses that invade a red cell are quickly destroyed, since the red cell collapses, preventing the virus from reproducing.

But with 2 sickle cell genes, red cells collapse too easily; just a bruise can cause someone to become anemic when too many red cells collapse.

In the real world, people with no sickle cell genes died from malaria. People with 1 sickle cell gene survived. People with 2 sickle cell genes died from sickle cell anemia.

It was natures way of assuring that at least half of the population survive, but it is certainly a difficult thing to live with today, now that we can more easily treat malaria.

The incidence of sickle cell disease is equal in both men and women.

However, it is believed that men who have the disease experience worse symptoms than women with the disease.

A possible reason for this is the role of oestrogen in the female body. Oestrogen helps stimulate the production of nitric oxide. Scientists believe that nitric oxide has a key role to play in reducing the symptoms of a sickle cell crisis as it dilates blood vessels, giving the sickle shaped cells more room to pass through the vessels, preventing blockages which is the cause of sickle cell crisis.

From my mom