Sickle-Cell Disease

Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is that the gene codes for a product that is for example used by various cells, or has a signalling function on various targets. A classic example of pleiotropy is the human disease PKU (phenylketonuria). This disease can cause mental retardation and reduced hair and skin pigmentation, and can be caused by any of a large number of mutations in a single gene that codes for an enzyme (phenylalanine hydroxylase) that converts the amino acid phenylalanine to tyrosine, another amino acid. Depending on the mutation involved, this results in reduced or zero conversion of phenylalanine to tyrosine, and phenylalanine concentrations increase to toxic levels, causing damage at several locations in the body. PKU is totally benign if a diet free from phenylalanine is maintained.

Sickle cell anemia and some nerve and brain disorders are examples of inherited diseases. These inherited diseases pass from parent to child via chromosomal exchange.

If you carry the sickle cell gene, it doesn't really mean much as far as your own personal health goes. Except that you are less likely to get malaria. However, if you decide to have kids, and whoever you mate with also carries the sickle cell gene (not the full blown disease/gene) , your child has a chance of having sickle cell disease (full blown).

The sickle cell allele can have a point mutation where a single nucleotide is changed, resulting in the substitution of glutamic acid with valine in the beta-globin chain of hemoglobin. This leads to the characteristic sickle-shaped red blood cells in individuals with sickle cell disease.

People with sickle cell disease are not immune to West Nile virus. However, they may be at a higher risk for severe complications if they do contract the virus due to their weakened immune system. It is important for individuals with sickle cell disease to take precautions to prevent mosquito bites and reduce their risk of being infected with West Nile virus.

Heterozygotes - those with sickle cell trait - show resistance to malaria. Therefore the survival rate of those with one sickle cell allele is higher than those with none - allowing for the trait to be passed on more frequently.

Sickle cell disease is a group of disorders that affects molecule in red blood cells (hemoglobin) that delivers oxygen to cells throughout the body. Person with this disorder have typical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

The higher frequency of the HbS allele in Africa is due to historical selective pressure from malaria. People with one copy of the HbS allele have increased resistance to malaria, providing a survival advantage in regions where the disease is prevalent. In the US, where malaria is not as common, there is less selective pressure for the allele to be maintained at high frequencies.

Thalassemia is a quantitative problem of too few globins synthesized, whereas sickle-cell anemia (a hemoglobinopathy) is a qualitative problem of synthesis of an incorrectly functioning globin. (wikipedia)

Sickle cell anemia is a genetic blood disorder affecting individuals who inherit two copies of the abnormal hemoglobin gene from both parents. This primarily affects people of African, Mediterranean, Middle Eastern, and South Asian descent.

Sickle cell disease is caused by a mutation in the gene that encodes for hemoglobin, a protein in red blood cells that carries oxygen. This mutation results in the production of abnormal hemoglobin known as hemoglobin S, which causes red blood cells to become sickle-shaped and less flexible.

Sickle cell anemia is a recessive genetic disorder caused by a mutation in the HBB gene, located on chromosome 11. It is inherited in an autosomal recessive pattern, meaning a person needs to inherit two abnormal copies of the gene (one from each parent) to have the disease. It is not an X-linked disorder or a multifactoial trait.

If you are heterozygous this means you carry both a dominant and recessive allele. if you are heterozygous for a recessive trait then you will have a dominant and recessive allele. example: let T represent tall and t represent short. a person with heterozygous for a recessive trait will have 'Tt'.

Some diseases are the result of adaptations to an environment. As it turns out, Sickle Cell Anemia is an adaptation to Malaria. If a person has a single copy of the Sicke Cell gene, he or she is protected against Malaria. If he or she has NO copies of the gene, he or she will die if exposed to Malaria. If he or she has two copies of the gene he or she will die from Sickle Cell Anemia. Malaria was fatal to pretty much everyone. The genetic mutation allowed about half of the population of the region to live. Today, we no longer have the threat from Malaria so now Sickle Cell Anemia becomes the problem.

Approximately 100,000 people die each year from complications of sickle cell disease, with most deaths occurring in sub-Saharan Africa. Early detection, proper management, and access to healthcare can help improve outcomes for individuals with sickle cell disease.

yes

An example of point-mutation is sickle-cell anemia. Sickle-cell disease is hereditary.

Peope with sickle cell disease suffer from pain crisis in arms,legs or ,chest. Well at least my daughter do. It is painful and she has to be admitted to hospital and receive morphine and. Iv fluids to relieve pain.

once youdidn't get it from birth, then it is not possible to get it when you grown up, but if you want to protect your future children not get the disease than it is better not to married from sickle cell disease man

It is impossible to predict what will happen with one person!

In a population of 2,000 people, 1,000 women have sickle cell trait and 1,000 men do not. They marry. Each couple has 2 children. 1,000 children will have sickle cell trait and 1,000 children will not.

In a population of 2,000 people, 1,000 women have sickle cell trait and 1,000 men have sickle cell trait. They marry. Each couple has 2 children. 1,000 children will have sickle cell trait, 500 children will not, and 500 children will have sickle cell anemia.

No one knows which of those parents will produce which children. No one knows how to predict how your children will turn out.

Yes

Exercising cost lot of energy.So Oxygen requirement increase.People with sickle cells, do not have normal number of blood cells to carry Oxygen.So energy production would not be sufficient.

People who have sickle cell should try to avoid consuming alcohol if at all possible. This is because sickle cell causes the patient to become dehydrated in the first place, so drinking alcohol would only exacerbate the problem.

Sickle cell anemia is an autosomal recessive disorder. It can result from two carriers having a child together.