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Vaccinations

A vaccine is the preparation of dead microorganisms, living weakened microorganisms or inactivated toxins. Its administration induces the development of immunity and protection against a pathogen or toxin and is called a vaccination.

1,376 Questions

Why do some people have side effects from a vaccine but others do not?

People may have different responses to vaccines due to variations in their immune systems, genetic makeup, or underlying health conditions. Additionally, factors such as age, gender, and previous exposure to similar antigens can also influence how individuals respond to vaccines. It is normal for people to have varying reactions to vaccines, as they provoke the immune system in different ways.

What must a vaccination contain to make it effective in producing immunity?

A vaccination must contain either a weakened or inactivated form of the disease-causing pathogen, or specific pieces of the pathogen such as proteins or genetic material. This prompts the body's immune system to recognize and remember the pathogen, allowing it to quickly mount a response if the person is exposed to the actual pathogen in the future.

Why is thimerosal considered safe when mercury is not?

Why is salt considered safe while chlorine gas is not? Compounds don't always have the same properties as the individual elements they are made of. The deadly chlorine is bound to sodium (also not safe to consume) to make a newcompound that is not only harmless, but necessary for life. Each chemical has to be tested and confirmed safe as it is, not on how it's individual parts behave.

What do doctors think about Swine Flu?

I am not able to speak to what all doctors think, but research I've done indicates that the majority in the US medical community (and most if not all parts of the world) think that the swine flu (H1N1/09) during the 2009 pandemic was a mild disease for the majority infected. It was fast-spreading. It affected some populations (such as the young and healthy, pregnant women, etc.) with more complications than those groups usually experience with the typical seasonal flu. It did not infect or kill as many in the over 65 age group, which usually is harder hit with deaths from the seasonal flu. It is unknown why they had less risk with this disease, but some think they may have acquired some aspect of protection from exposure to other similar types of flu sometime in their lifetimes.

The microbiologists, epidemiologists, and medical practitioners understand the science of the disease and research that indicates that it was caused by a reassortant (mutation/combination) of common strains of flu in swine, humans, and birds that resulted in the new strain. Although this was a new mutation and could have been devastating to the population of the world if it had caused a higher mortality rate, especially since it spread so easily and since there was no inherited or acquired immunity available in the population from prior exposure to the specific strain, they realize that good public education, fast responses by the medical and public health communities and quick development of vaccines all contributed to the control of the new disease and the actual results compared to the potential results that existed and were creating all the concern among world scientists.

I personally, as a member of the medical community, believe that the entire experience was valuable for the world community as preparation for what will likely happen in future epidemics, and it will have provided a good trial of our preparedness and responses to pandemics and threatened pandemics in the future. If we continue to practice good hygiene and avoid the spread of our germs with these improved practices and cough and sneeze etiquette, we will all be better prepared and safer in future situations of new forms of infectious disease.

This situation proved the value and safety of flu vaccinations as well. Millions were vaccinated and protected from disease with a significantly low number of adverse effects reported.

Be safe and protected by getting and having your children treated with routine vaccinations for diseases.

What is the development of vaccines by edward Jenner and Louis Pasteur?

Edward Jenner developed the first successful smallpox vaccine in 1796, using material from cowpox lesions. His work laid the foundation for modern vaccination techniques. Louis Pasteur further advanced the field of vaccination by developing vaccines for diseases like rabies and anthrax in the late 19th century, demonstrating the concept of attenuating pathogens to create effective vaccines. Together, their contributions revolutionized the field of immunization and have saved countless lives.

Can antigenic proteins from certain pathogen be used for vaccines?

Yes, antigenic proteins from specific pathogens can be used to develop vaccines. These proteins can stimulate the immune system to produce antibodies and memory cells that can recognize and protect against future encounters with the pathogen, thereby providing immunity.

What is the liquid portion of a vaccine called?

The liquid portion of a vaccine is called the diluent or excipient, which serves as a medium for the active ingredients in the vaccine. It helps stabilize and maintain the vaccine's potency and efficacy.

Which vaccine is produced by using only a part of the viral genome?

Subunit vaccines are produced using only a part of the viral genome. These vaccines use specific proteins or fragments of the virus to stimulate an immune response without causing infection. An example of a subunit vaccine is the Hepatitis B vaccine.

Which cells make you immune to a disease that you were previously exposed to?

"Memory B cells" of the immune system stay in your body after an infection to enable quick immune responses to the disease-causing organism (antigen) if later exposed again. Antibodies are proteins made by the type of white blood cells called B-cells/"plasma cells" in response to the presence of antigens. The antibodies attach to the B-cells as "B-cell Receptors" to activate them, and can cause them to become either the memory B-cells or more plasma cells.

What does Most bacterial vaccines contain?

There are 2 types of vaccines:

(1) Live ("attenuated", or bred to be harmless)

(2) Killed (dead disease-causing particles)

Live vaccines can be more effective, don't usually need 'booster' shots later to make them work better, but are less able to be given to immunocompromised or pregnant people as they are still alive.

Killed vaccines are less effective, often requiring boosters, but can be given to immunocompromised people and (often) pregnant ladies. They are used with an "adjuvant", or a substance that helps them work better (makes your body more able to make antibodies to them faster).

Both types of vaccines have 'epitopes', or molecules that your body recognises. These epitopes are the SAME as what is on the actual disease-causing particles. This is why they work - your body sees the "HARMLESS" particles and learns to recognise them, or creates "antibodies" that help your body respond to the actual thing when it appears.

It takes time to create these antibodies, so if you can make them BEFORE the actual disease finds its way into your body, you can respond much faster and destroy the virus particles before they can cause you harm.

The type of vaccine depends on what has been developed. There are benefits of both ways, but it is not always easy to do both.

Side note: occasionally, you will hear about how "vaccines are horrible, and cause more harm than good". Most of the time, people use multi-resistant organisms as examples, however, these organisms become resistant to ANTIBIOTICS, and NOT vaccines! Having antibodies is natural, unlike many antibiotics! They are NOT comparable! Antibodies are a post-infection method of disease control, whereas vaccines prevent the disease from establishing. Thus, vaccines have in the past been used rather successfully to rid the world of several diseases! (Which we can ALL be extremely grateful for!!!!!)

Another poorly-used example was that of the smallpox vaccine causing many deaths. Reasons why this example is tragically misused is that it was the first-ever attempt at vaccination in recorded history (we no longer live in such an age where we must rely on random human-testing of live NON-attenuated pathogen injection!). Smallpox protection included injecting pus from the lesions of an infected person (or another vaccinated person) to create antibodies.

Case in point: we no longer inject pus into people... it's a good way to spread other infections, and is less reliable in results. We no longer live in the 'dark ages' of immunology. The first attempts at reaching space failed badly, and yet nobody seems to be boycotting space travel now that science and technology has improved, so please be open-minded if anyone ever tells you that in vaccines, in general, are "bad". Okay? :)

What is Menactra vaccine?

It is a vaccine for the prevention of bacterial meningococcal disease and meningitis (infection of the covering of the brain and spinal cord).

From manufacturer package literature:

"Menactra vaccine is indicated for active immunization to prevent invasive meningococcal disease caused by N meningitidis serogroups A, C, Y, and W-135. Menactra vaccine is approved for use in individuals 9 months through 55 years of age. Menactra vaccine does not prevent N meningitidis serogroup B disease. "

What are vaccines for influenza made from?

If the influenza vaccine is to be made from a live virus, then the strain is selected, grown, and then weakened (usually chemically) to be able to trigger an immune response but not be strong enough to cause the infection. If it is to be made using a "dead" or inert virus that also does the same to trigger immune response and antibody production without causing infection, then the virus is grown and then made inactive before being used in the vaccine.

Once the virus particles needed are produced one of the two ways above, they are purified, isolated and combined with administration medium that is either for injection or for use with a mist/inhalation administration medium.

There are sometimes adjuvants added that will make a little go a long way (these are not used in the US flu vaccines). This way smaller doses are needed and so more vaccine can be distributed to more people in shorter times. This is helpful if the strain is not easily or quickly grown and vaccine is needed quickly.

There are also preservatives added to maintain the purity of the vaccine. This is needed especially in multi-dose vials that are not used entirely upon opening of the sterile vials. Single dose vials and syringes are usually available without the addition of these preservatives for people with special needs or Allergies to the preservatives.

For a full list of the common ingredients used today in flu vaccines, see the related question below about the specific ingredients in the swine flu vaccine.

How have vaccines changed the world?

Hello there!

Vaccines have saved many lives, especially from nasty viruses like smallpox and poliomyelitis which claimed several human lives, and other terrible bacterial infections like diphtheria, pertussis, Haemophilus influenzae infections in children, to name a few.

So yeah, vaccines have saved many lives, including mine and yours as well and that is why many of us don't have paralysis either from polio and so on.

Hope this helped you! 😄

What cells give vaccines the ability to make people immune?

Vaccines contain dead or weakened versions of a virus. The body then develops a defense against this virus so that the next time the real virus comes along, the body can identify it and fight it off.

This process of defense development takes place in the immune system of the body. Specialized cells (called b-cells) are created by the bone marrow. These are the cells that produce antibodies. Antibodies work to attack and disable antigens (foreign particles or organisms that have invaded the body, or that the body thinks are invaders). Once the body has developed antibodies for a particular invader, the pattern of those antibodies is stored by the immune system, and duplicates can be readily produced to attack if that invader, or one like it, is detected again. That is what gives you immunity.

See the related questions below for additional information.

Are the microbes that are injected in a vaccination dead or alive?

They can be either. Some vaccines are made with dead viruses or particles of viruses and other vaccines are made with attenuated (weakened) viruses that are not able to make an otherwise healthy person sick. In 2009 the swine flu vaccine approved for use in the US was prepared both ways, the nasal flu vaccine was made from attenuated viruses and the shots were made with dead viruses.

What is an advantage of the use of vaccinations to fight bacterial diseases?

Vaccinations can provide long-term protection against bacterial diseases by stimulating the immune system to produce antibodies. This helps prevent infection and reduce the spread of bacterial illnesses within a population. Vaccinations can also lower the overall burden of disease, saving lives and reducing healthcare costs.

What is a vaccine for bacterial meningitis?

There are vaccines available for certain types of bacterial meningitis, particularly caused by Neisseria meningitidis and Streptococcus pneumoniae bacteria. Vaccines like MenACWY and PCV13 help protect against these bacteria by stimulating the immune system to produce antibodies against them. Vaccination is an effective way to prevent bacterial meningitis and its complications.

What are cell culture based vaccines?

Cell culture-based vaccines are vaccines that are produced using cell cultures rather than traditional methods involving live organisms or eggs. By using cell cultures, these vaccines can be produced more rapidly, with greater consistency and purity. This technology also reduces the risk of contamination and allows for the production of vaccines against viruses that cannot be easily grown in eggs.

What is the risk associated with vaccines prepared from dead or weakened pathogenic microbes?

In the US there are two types of vaccines approved for the seasonal flu, a vaccine for injection into the muscle and a vaccine mist for spray into the nose. The side effects are different depending on which you use. The mist is only available to healthy people age 2 - 49. The shots are approved for use in anyone 6 months old and over unless there are allergies that prevent their use. Infants under 6 months old can not be vaccinated until they are older.

The shots use a dead virus and the nasal mist is made with attenuated (weakened) viruses that can't make you sick if you have an otherwise normal immune system.

They are made exactly like they have been made for decades with an exceptionally good track record of low incidence of adverse effects or allergic reactions.

Life-threatening allergic reactions to vaccines are very rare. If they do occur, it is usually within a few minutes to a few hours after the vaccination. It is recommended that you report to the nurse before you receive the vaccination if you have any medication or food allergies (especially to eggs or chicken).

The most commonly reported side effects of thenasal mist include:

  • Some children and adolescents 2-17 years of age have reported mild reactions, including: runny nose, nasal congestion or cough; fever; headache and muscle aches; wheezing; abdominal pain or occasional vomiting or diarrhea.
  • Some adults 18-49 years of age have reported: runny nose or nasal congestion; sore throat; cough, chills, tiredness/weakness; headache.

The most frequently reported side effects of the flu shots are:

  • Mild hypersensitivity reactions (such as rash).
  • Local reactions at the injection site such as tenderness, redness, swelling, pain or soreness.
  • The most common systemic adverse reactions were headache, malaise, and muscle aches. Fever is rare, but a very mild fever is possible the first day or two.

In 1976, an earlier type of inactivated swine flu vaccine was associated with cases of Guillain-Barré Syndrome (GBS). There has not been any link to GBS with the use of the nasal mists.

The shots are made an entirely different way now than they were made in the 1970's. The new way has been proven for over 30 years.

What is the difference between vaccine and antibiotic?

Antibiotics treat current infections. Vaccines create antibodies to deal with a future infection.

When did the H1N1 vaccine come out?

A while ago. It just recently started being given out to patients.

P.S - I would recommend this shot. I felt a little light headed the next day but I won't get the flu so it's all worth it !

Why are scientists using eggs to develop the swine flu vaccine?

To make vaccine for a program of vaccinations in a population group, first the scientists need a certain amount of the virus that can be turned into the weakened version of the virus to use in the vaccination. Since viruses are not really alive, and since they need a host to provide cells to do the work of their reproduction for them, the scientists give them the egg as the host and, just like the virus makes our bodies do when we catch a cold or flu, it will make the egg cells do the same thing to make more virus particles so the scientists can grow a supply from which to make the vaccine.

For a full explanation of this process, see the related link section below.

How do you know if you need the BCG Vaccine?

BCG i.e. bacille Calmette Guerin vaccine used to prevent tuberculosis and also given to prevent compications like such as meningitis in many countries ( not in US). The BCG vaccine confers a positive PPD skin test result but appears to protect only about half of those inoculated