Why are people with sickle cell trait resistant to malaria?
Not sure if this is right but could it be because the blood cell does not contain enough oxygen for the parasite to survive?
Why do sickle cell anemia cause so many problems?
A sickle cell is a malformed red blood cell. It is caused by a mutated gene inherited from one or both parents. If inherited from both parents the red cells are very malformed, causing sickle-cell anaemia. This is a serious illness, causing weakness and shortness of breath and often leading to an early death.
Mutations like this are usually steadily removed from the gene pool because those with it tend to have fewer children. The sickle-cell gene remains in the gene pool because those who get it from only one parent have a slightly deformed red-cell. This causes only limited problems for the bearer, and has one large advantage - it makes the red-cell taste nasty to the malaria parasite. In other words, it protects against malaria which is otherwise often fatal.
In areas where malaria is endemic it is common to find the sickle cell gene in about 15% of the population. When Africans came to the USA as slaves the gene came with them. However, malaria has never been common in the US, and the percentage of sickle-cell gene in black Americans has decreased steadily.
What is the relationship between sickle-cell disease and malaria?
G6PDD does not protect against malaria infection. People with G6PD Deficiency can still get it like anyone else. The malaria larva has to have mature red blood cells to live in and cannot survive in immature ones. An rbc's normal life span is 120 days, but due to hemolysis, many do not live this long. The faster death of rbc's also causes the malaria larva to die as well. There are two problems with this. The first is obvious as hemolysis (death of rbcs) also causes us problems. Although G6PD Deficient people are spared the severe symptoms of malaria, they have to weather hemolysis and must rely on their ability to make new rbcs. The infection is still sequestered in their liver. The second is that there is no anti-malarial medication that is friendly to G6PD Deficient people.
Malaria is dangerous and precautions should be taken to avoid infection. Anti-malarials are not an option. You can learn more about this at g6pddeficiency.org.
How does having anemia affect oxygenation?
Anemia is the reduction of either the number of red blood cells, or the amount of hemoglobin in the red blood cells. This results in a decrease in the amount of oxygen that the blood is able to carry.
Anemia reduces the amount of oxygen available in the cells of the body. As a result, you have less energy available to perform normal functions. Important processes, such as muscular activity and cell building and repair, slow down and become less efficient. When the brain lacks oxygen, dizziness may result, and mental faculties are less sharp.
Does sickle cell appear at birth or later on in life?
It is evident as soon as you are born if you have it.
Does sickle cell anemia affect certain groups of people more than others?
It affects those who are carriers as well as those who have the disease fully. Carriers though have both sickle cell blood cells and normal ones, and therefore can usually function just like other people would.
It is most often seen in African-Americans.
What is a common symptom of anaemia?
Some are :
What can make a person anemic?
Anemia can be caused by inadequate production of red blood cells, increased destructions, or excessive loss. Iron deficiency anemia is a common cause in menstruating women.
red meat
How frequently does iron deficiency anemia occur?
Hemophilia occurs in approximately 1 in every 5,000 male births. Females can be carriers, symptomatic, or full hemophiliacs themselves and should in theory have a slightly higher prevalence of the genetic trate. It would be safe to say that more than 1 in 5000 people born, cary the genes for hemophilia. Roughly 1 in 10,000 births are males with hemophilia.
What type of mutation cause cell anemia?
Mutations in the hemoglobin molecules cause sickle cell anemia.
Why do people suffering from anaemia get tired easily?
Iron is needed to produce haemoglobin, which is the part of the blood that carries oxygen throughout the body. A lack of haemoglobin means less oxygen available to be utilised by cells for energy
Why does chronic renal failure usually result in anemia?
Certain cells in the kidney (juxtamedullary apparatus) detect blood flow to the kidney, so the body can measure the volume of blood and the amount of red blood cells in it. When the number of red blood cells in the blood gets too low, this is called anaemia. When this happens, the juxtamedullary cells detect it and can stimulate the release of a hormone called erythropoetin, which causes the bone marrow to make more red blood cells. This corrects the anaemia. Erythopoetin is also produced naturally (when not anaemic) to maintain normal numbers of red blood cells.
As the juxtamedullary cells are part of the kidney, when the kidney fails, they do too. They lose their ability to produce erythropoetin. The bone marrow stops producing normal numbers of red cells and anaemia can result.
Is craving ice a sign of anemia?
Craving ice is more likely a sign of some dehydration and/or fever than as an indicator of anemia. The only sure way to know if you are anemic is through blood tests of a Complete Blood Count (CBC). If you have a fever, a "Diff" (Differential) would be added to the bloodwork. If you are dehydrated, eating ice is not enough to replenish fluids.
An individual diagnosed with anemia has a low count of red blood cells why do they lack energy?
Because iron is necesary in the production of red blood cells. Since its job is pretty much to bond with oxygen and take it to its place the cells are only produced at the rate that the iron allows it to. Low iron=low Blood cell Count=anemia. Iron can be found in spinach, beef, peanutbutter, iron pills...ect
What causes skin on inner thighs to look spotted?
Inner thigh spots or darkening is caused by friction when walking. Normally the upper thighs for either male or female are usually close to each other and when one walks it causes friction which could lead to the above mentioned. You could try using lotion with vitamin E to neutralize your skin color or if it makes you self conscience check with your dermatologist for better advice on skin products.
yes there are two concentrations of sickle cell
they are:
sickle cell trait: co-dominance is established and only 50% of your cells are malformed
sickle cell anemia: sickle cell is totally dominant and all cells are malformed, this only happens when both alleles are coded for sickle cell
Explain why excessive bleeding occurs with a plastic anemia?
i think the cause of plastic anemia is the lack of red cell in the bone marrow
A cell with a defective p53 gene is likely to?
A defective P53 gene is likely to cause poor regulation of cell cycles. P53 is a protein that suppresses tumor production and is implicated as a factor in cancer development. It prevents genome mutation and damage. 50% of human tumors have mutated or deleted P53 genes.
How is Waldenstrom's macroglobulinemia related to anemia?
At least 50% of individuals with WM have hyperviscosity syndrome, an increased viscosity or thickening of the blood caused by the accumulation of IgM in the serum.
How is iron deficiency anemia characterized?
There are a number of characteristics that will show when children have an iron deficiency. Children with an iron deficiency are typically cold and pale.
This mineral is essential for healthy red blood cells and a deficiency causes anemia?
Grossly speaking IRON is the answer but on an whole lot other minerals can lead to anemia if they are deficient.
Can parasite cause severe anemia?
Yes, absolutely. If you even SUSPECT this, go to a doctor immediately, and ask him or her to specifically screen for parasites , and if you can possibly afford it, ask for a refferal to a specialst in Tropical Medicine, or go to a University hospital, as they will more likely have a Parasitologist handy.Good for you for being pro-active with your health care. Don't stop til you get an answer.