Sickle-Cell Disease

Well if you don't keep dry lips moist they can crack and end up bleeding getting cracks in your lips i would fine a good chap stick to use your lips might end up having sores on them become hard to heal keep them moisturized the best you can do is use abreva to heal the sores and blisters.

Diarrhea

No, not unless you are ill.

There is an increased possibility of a stroke or heart attack that may often result in death. It is best to ask your doctor for a personal reccommendation on consuming alcohol and the effects it may have on your health. To prevent further complications to the disease it is best to adopt a healthy lifestyle involving limited or no alcohol intake, healthy balanced diet and exercise. Smoking should be avoided at all cost, and it is essential to consume at least 8 glasses of water a day to prevent dehydration. If you do consume alcohol, drink 1 - 8oz glass of water for every 1oz of liquor or 4 oz glass of wine or 6oz of beer. This will limit the effects of dehydration which may cause stroke.

Sickle cell disease predominantly affects individuals of African, Mediterranean, Middle Eastern, and Indian descent. It can also affect people from other regions with a history of malaria, as the sickle cell trait provides some protection against the disease.

malaria. This resistance is due to the fact that the sickle cell trait confers some protection against the malaria parasite, Plasmodium falciparum, making individuals less susceptible to severe malaria infections.

The parents are both recessive (Ss) for sickle cell anemia.

yes

Some celebrities who have openly discussed having the sickle cell trait include Tionne "T-Boz" Watkins of TLC and Solange Knowles, sister of Beyoncé.

Sickle cell disease is an autosomal reccessive sexlinked trait so, a female msut have 2 recessive alleles to have the trait and a male needs only one allele (this is because there is no corresponding site for this allele on the Y chromosome.

The female can be a carrier of the disorder with the defective allele on one X chromosome and a normal allele on the other X chromosome. Female carrriers can have a mixture of normal and abnormal redblood cells.

not being able to work because of fatigue, being sick or doctors appointments can have a negative effect on your work place and as a result the economy

I think so. I played with it as a forward and it was a challange at the start but i was able to get through it. Just make sure you hydrate alot and you take meds/take a break the moment you have pain.

sickle cell disease is also a sickle cell anemia is a hereditary problem. It causes type of faulty haemoglobin in red blood cells. Human red blood cells will be circular in shape, so that it can run properly and move flexible in blood vessels but Sickle cell anemia will be in sickle or like crescent moon shape, so that they cant move well in small blood vessels and it blocks the blood vessels. If the blood vessels are blocked it causes low supply of oxygen to body organs and it causes severe pain, infection, jaundice and may also cause strokes. It also leads to death of a person.

Yes, it would not prevent it, however, if they are being treated, they should discuss it with their physician to avoid problems with medication preventing clotting or similar issues.

The possibility of finding a cure for sickle cell disease has significantly increased with advancements in gene therapy and editing technologies, such as CRISPR. Clinical trials have shown promising results, with some patients achieving remarkable improvements or even remission. However, challenges remain, including ensuring the safety, accessibility, and affordability of these treatments. Continued research and investment in this area are critical to making a definitive cure a reality.

In haemoglobin, there are four polypeptide chains that make it's structure, 2 (A) chains and 2 (B) chains. Sickle-Cell Anemia is caused by a mutation the (B) chain that makes the haemoglobin molecules stick to each other and form fibres inside the red blood cell (RBC).

Instead of a circular disc shaped RBC we now have a sickle shaped cell. This means transport of oxygen is very innefficient and the disease can cause death.

However, in areas with a high malaria rate, heterozygous sickle-cell anaemics (with some sickle shaped AND normal RBCs) are naturally selected because the protozoan (what causes the disease) is unable to live inside the red blood cell due to the fibres formed from the mutation, the cells are more fragile and they have a shorter life span than normal RBCs. This means that people with heterozygous alleles for sickle-cell anaemia benefit against malaria and will survive to reproduce, which increases the allele frequency of the sickle-cell anaemia allele.

Those with homozygous sickle-cell anaemia and those with homozygous normal haemoglobin are selected against as the first usually die of the sickle-cell anaemia, and the latter contract malaria.

NB. Mutations are rare occurrences. It is even rarer for a mutation to give selective advantage. This mutation for sickle-cell anaemia did not happen to 'cure' or prevent malaria, it was a random occurrence that coincidentally gave a selective advantage against malaria.

if you are in pain drink a lot of water take any medication you have to take relax your mind and don't let the pain take control of you. At first I tel the pain control me and it cause it to be worst. So drink and just relax and if it gets worse call a doctor.

Sickle cell anemia is not a contagious disease, so it cannot spread from person to person. Instead, it is a genetic disorder caused by inheriting specific mutations in the hemoglobin gene from both parents. The prevalence of sickle cell anemia is higher in certain regions, particularly in Africa, the Mediterranean, and parts of India, due to historical resistance to malaria in carriers of the sickle cell trait. Efforts to manage and treat the condition focus on genetic counseling and public health initiatives rather than containment of spread.

It affects the red blood cells as they are an abnormal shape and can not fit through the spleen so therefore breakdown faster

No. It can be found in Africans all over the world.

Sickle cell anemia is a gentic disease carried by people of African and sometimes Indian decent. Although both parents need to at least carry the gene for their children to get it not necessarily have the disease.

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