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Neuropharmacology

Studying the science of drugs that effect the brain and nervous system. Ask questions about drug-induced changes both behavioral and molecular.

92 Questions

Why phenobarbitone has been rarely used nowadays?

due its sedating property, wide range of drug-drug interactions and can depress our cognitive functions. It can also induce osteoporosis with prolonged use.

It's preferably to be used in refractory cases of epilepsy only.

How is the ionic composition in a neuron affected at the start of a nerve impulse?

At the start of a nerve impulse, also known as an action potential, there is a rapid change in the ionic composition of the neuron. Sodium (Na+) channels open, allowing Na+ ions to flow into the cell, which depolarizes the membrane and shifts the internal charge from negative to positive. This depolarization is followed by the opening of potassium (K+) channels, allowing K+ to exit the cell, which eventually helps to repolarize the membrane. The coordinated movement of these ions is crucial for the propagation of the nerve impulse along the neuron.

What pair of chemicals work together to form the neuroendocrine system?

Neurotransmitters and hormones work together to form the neuroendocrine system.
Neurotransmitters and hormones- Apex

What is an example of neuroleptanesthesia?

An anesthetic state that may be induced if neuroleptic-opiod combination is ineffective. In addition to a neuroleptic and an opioid (droperidol + fentanyl), concurrent administration of 65% nitrous oxide (laughing gas)= patient will be unconscious.

How to avoid giving levodopa in high dose to Parkinson's patients?

Although levodopa can cross our BBB, but it will be decarboxylated to dopamine peripherally before reaching our CNS - only small amount of Levodopa will be left and available to pass our BBB.

So, instead of giving levodopa in high dose (which can cause lots of side effects), we give levodopa with peripheral decarboxylase inhibitors (e.g. carbidopa, benserazide) which can inhibit decarboxylation of levodopa in GIT and peripheral tissues. (By combining levodopa and peripheral decarobxylase inhibitors, we will have less side effects too)

What is levodopa?

To make it simple, Levodopa is the precursor of Dopamine and it's used to treat Parkinson's disease. (We don't directly use dopamine because dopamine can't cross our blood-brain-barrier, so, it won't be effective to be taken orally)

What neurotransmitter does a SNRI 'Serotonin Norepinephrine reuptake inhibitor' drug work on?

The S stands for serotonin and the N stands for norepinephrine and RI stands for reuptake inhibitor. So, obviously these drugs are supposed to work on both serotonin and norepinephrine. However, some literature uses SNRI to mean Selective Norepinephrine Reuptake Inhibitor, and this will work better on norepinephrine. Then you have the SSRI which is Selective Serotonin Reuptake Inhibitor, which works better on serotonin.

What are the contraindications of levodopa?

We don't give levodopa to:

  • psychiatric patients (because it will antagonize the effect of antipsychotics)
  • glaucoma patients (because it can increase our intraocular pressure)
  • peptic ulcer patients (because it might cause hemorrhage)

Tricyclic antidepressants compared to selective serotonin re-uptake inhibitors?

Tricyclics are more potent antidepressants compared to the newer SSRIs. The reason SSRIs tend to be prescribed more, however, is because tricyclics are less well tolerated due to their antimuscarinic effects, such as: dryness of mouth, constipation, dizziness, abnormal heart rhythm, blurred vision and urinary retention. Trycyclics cannot be given to people with with hypotension or heart problems. SSRIs generally have a longer half life (15-50 hrs vs. 12-32 hrs for trycyclics) and do not require as high a concentration in the blood as tricyclics for their therapeutic effect.

Why does starch react with iodine solution?

Iodine (a halogen) forms a starch-iodine complex by binding with amylose coils, which results in a transfer of charge between amylose and iodine, changing the energy levels of iodine atoms, and producing a dark blue color.

What forms are tricyclic antidepressants administered in?

Tricyclic antidepressants are available only with a physician's prescription and are sold in tablet, capsule, liquid, and injectable forms

Where was the oil spill and how did it happen?

If you mean the big spill that just happened, It happened in the gulf of Mexico and started when a BP oil rig caught on fire and sunk into the ocean, which is now spilling oil miles below the sea under water. Gee, thanks BP. Hope this helped!

Which general anaesthesia is contraindicated in asthmatic patients?

desflurane (because it can cause respiratory infection - cough, bronchospasm)

What is the effect of cannabis on synapse transmission?

nothing it is perfectly safe

ANSWER

Cannabis is not "perfectly" safe, nor is is certainly dangerous. No one is completely certain of its full effects the chemical function of the brain is not fully elucidated, nor are the complete effects of cannabis on this complex system. What is known is that the active ingredient, THC, effects cannabinoid mediated neurotransmission in the brain on binding to CB1 receptors. Binding to these receptors causes a reduction in the activity of the inhibitory neurotransmitter GABA in decreasing its release. CB1 is the most widely identified receptor in the adult brain.

What are the antagonists to antipsychotics?

  • any drugs that can increase dopamine concentration at synapses:
    • L-dopa
    • amphetamine
  • any drugs that mimic dopamine action : e.g. bromocriptine

What is peristaltic movement and how does it function in the esophagus?

The peristaltic movements are muscle contractions and its function on the esophagus is to push food down into the stomach and prevent it from going back into the esophagus.

What is an hedonic shift?

In behavioral neuropharmacology, this refers to a shift in the 'pursuit of pleasure.' Stimulation of cannabinoid receptors, for example, can cause a hedonic shift in food consumption.

What are the contraindications of morphine?

We don't give morphine for patients suffering from:

  • head injury : because it can depress the respiratory centre and increase intracranial pressure
  • bronchial asthma : because histamine release will cause bronchiol-constriction
  • pregnancy : might lead to fetal respiratory depression and withdrawal syndromes in newly born
  • impaired renal or hepatic functions
  • myxedema : because it can decrease basal metabolic rate
  • old people and infants : can cause respiratory depression
  • shocked patients : can cause severe hypertension
  • acute undiagnosed abdominal pain