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spina bifida

 
American Heritage Dictionary:

spi·na bif·i·da

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(spī'nə bĭf'ĭ-də) pronunciation
n.
A congenital defect in which the spinal column is imperfectly closed so that part of the meninges or spinal cord protrudes, often resulting in hydrocephalus and other neurological disorders. Also called schistorrhachis.

[New Latin spīna bifida : Latin spīna, spine + Latin bifida, feminine of bifidus, split in two.]


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Oxford Food & Nutrition Dictionary:

spina bifida

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Congenital neural tube defect due to developmental anomaly in early embryonic development. Supplements of folic acid (400 μg/day), begun before conception, reduce the risk.

Gale Encyclopedia of Children's Health:

Spina Bifida

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Definition

Spina bifida is a birth abnormality in which the spine is malformed and lacks its usual protective skeletal and soft tissue coverings.

Description

Spina bifida may appear in the body midline anywhere from the neck to the buttocks. In its most severe form, termed spinal rachischisis, the entire spinal canal is open, exposing the spinal cord and nerves. More commonly, the abnormality appears as a localized mass on the back that is covered by skin or by the meninges, the three-layered membrane that envelops the spinal cord. Spina bifida is usually readily apparent at birth because of the malformation of the back and paralysis below the level of the abnormality.

Various forms of spina bifida are known as meningomyelocele, myelomeningocele, spina bifida aperta, open spina bifida, myelodysplasia, spinal dysraphism, spinal rachischisis, myelocele, and meningocele. The term meningocele is used when the spine malformation contains only the protective covering (meninges) of the spinal cord. The other terms indicate involvement of the spinal cord and nerves in the malformation. A related term, spina bifida occulta, indicates that one or more of the bony bodies in the spine are incompletely hardened, but that there is no abnormality of the spinal cord itself.

Demographics

Spina bifida occurs worldwide, but there has been a steady downward trend in occurrence rates since about 1940, particularly in regions of high prevalence. The highest prevalence rates, about one in 200 pregnancies, have been reported from certain northern provinces in China. Intermediate prevalence rates, about one in 1000 pregnancies, have been found in Central and South America. The lowest prevalence rates, less than one in 2,000 pregnancies, have been found in European countries. The highest regional prevalence in the United States of about one in 500 pregnancies has occurred in the Southeast.

Causes and Symptoms

Spina bifida may occur as an isolated abnormality or in the company of other malformations. As an isolated abnormality, spina bifida is caused by the combination of genetic factors and environmental influences that bring about malformation of the spine and spinal column. The specific genes and environmental influences that contribute to the many-factored causes of spina bifida were not as of 2004 completely known. An insufficiency of folic acid is known to be one influential nutritional factor. Changes (mutations) in genes involving the metabolism of folic acid are believed to be significant genetic risk factors. The recurrence risk after the birth of an infant with isolated spina bifida is 3 to 5 percent. Recurrence may be for spina bifida or another type of spinal abnormality.

Spina bifida may arise because of chromosome abnormalities, single gene mutations, or specific environmental insults such as maternal diabetes mellitus or prenatal exposure to certain anticonvulsant drugs. The recurrence risk varies with each of these specific causes.

In most cases, spina bifida is obvious at birth because of malformation of the spine. The spine may be completely open, exposing the spinal cord and nerves. More commonly, the spine abnormality appears as a mass on the back covered by membrane (meninges) or skin. Spina bifida may occur any where from the base of the skull to the buttocks. About 75 percent of abnormalities occur in the lower back (lumbar) region. In rare instances, the spinal cord malformation may occur internally, sometimes with a connection to the gastrointestinal tract.

In spina bifida, many complications arise, dependent in part on the level and severity of the spine malformation. As a rule, the nerves below the level of the abnormality develop in a faulty manner and fail to function, resulting in paralysis and loss of sensation below the level of the spine malformation. Since most abnormalities occur in the lumbar region, the lower limbs are paralyzed and lack sensation. Furthermore, the bowel and bladder have inadequate nerve connections, causing an inability to control bowel and bladder function. Most infants also develop hydrocephaly, an accumulation of excess fluid in the four cavities of the brain. At least one of every seven cases develops findings of Chiari II malformation, a condition in which the lower part of the brain is crowded and may be forced into the upper part of the spinal cavity.

There are a number of mild variant forms of spina bifida, including multiple vertebral abnormalities, skin dimples, tufts of hair, and localized areas of skin deficiency over the spine. Two variants, lipomeningocele and lipomyelomeningocele, typically occur in the lower back area (lumbar or sacral) of the spine. In these conditions, a tumor of fatty tissue becomes isolated among the nerves below the spinal cord, which may result in tethering of the spinal cord and complications similar to those with open spina bifida.

Diagnosis

Few disorders are to be confused with open spina bifida. The diagnosis is usually obvious based on the external findings at birth. Paralysis below the level of the abnormality and fluid on the brain (hydrocephaly) may contribute to the diagnosis. Other spine abnormalities such as congenital scoliosis and kyphosis, or soft tissue tumors overlying the spine, are not likely to have these accompanying findings. In cases in which there are no external findings, the diagnosis is more difficult and may not become evident until neurological abnormalities or hydrocephaly develop weeks, months, or years following birth.

Prenatal diagnosis may be made in most cases with ultrasound examination after 12 to 14 weeks of pregnancy. Many cases are also detected by the testing of the mother's blood for the level of alpha-fetoprotein at about 16 weeks of pregnancy. If the spine malformation is not skin covered, alpha-fetoprotein from the fetus's circulation may leak into the surrounding amniotic fluid, a small portion of which is absorbed into the mother's blood.

Treatment

Aggressive surgical and medical management have improved the survival and function of infants with spina bifida. Initial surgery may be carried out during the first days of life, in the hope of providing protection against injury and infection. Subsequent surgery is often necessary to protect against excessive curvature of the spine, and in the presence of hydrocephaly, to place an echanical shunt to decrease the pressure and amount of cerebrospinal fluid in the cavities of the brain. Because of weakness or paralysis below the level of the spine abnormality, most children require physical therapy, bracing, and other orthopedic assistance in order to be able to walk. A variety of approaches including periodic bladder catheterization, surgical diversion of urine, and antibiotics are used to protect urinary function.

Although most individuals with spina bifida have normal intellectual function, learning disabilities or mental retardation occur in a minority. This deficit may result, in part, from hydrocephaly and/or infections of the nervous system. Children so affected may benefit from early educational intervention, physical therapy, and occupational therapy. Counseling to improve self-image and lessen barriers to socialization becomes important in late childhood and adolescence.

Open fetal surgery has been performed for spina bifida during the last half of pregnancy. After direct closure of the spine malformation, the fetus is returned to the womb. By preventing chronic intrauterine exposure to mechanical and chemical trauma, prenatal surgery improves neurological function and leads to fewer complications after birth. Fetal surgery is considered experimental, and results have been mixed.

Prognosis

More than 80 percent of infants born with spina bifida survive with surgical and medical management. Although complications from paralysis, hydrocephaly, Chiari II malformation, and urinary tract deterioration threaten the well-being of the survivors, the outlook for normal intellectual function is good.

Prevention

Prevention of isolated spina bifida and other spinal abnormalities became possible in the 1980s and 1990s. The major prevention is through the use of folic acid, one of the B vitamins, for several months prior to and following conception. The Centers for Disease Control and Prevention (CDC) recommend the intake of 400 micrograms of synthetic folic acid every day for all women of childbearing years. For women who have had a previous child with spina bifida, the CDC recommends a daily intake of 4 milligrams of synthetic folic acid to help prevent a recurrence of spina bifida in future pregnancies.

Parental Concerns

Caring for a child with spina bifida can be a daunting endeavor. Initially, parents may be overwhelmed with the medical decisions to be made and with the grief experienced after the birth of a special needs child. Many parents benefit from early and continuing involvement of an experienced social worker. There will be a multitude of medical decisions to be made. Children with spina bifida require a multidisciplinary team of healthcare providers, including surgeons, physicians, and therapists. Parents may find it helpful to designate a physician, usually the primary pediatrician, or an experienced rehabilitation counselor to act as an advocate for their child and to aid them in coordinating their child's treatment program.

Parental concerns may be two-fold, medical and emotional. Medical concerns include monitoring their child's condition after surgery. Children with spina bifida may have many surgical procedures throughout their lives. Post surgical complications are common but may often be avoided. Parents will be given care instructions after each surgery. Children with spina bifida face a multitude of heath issues such as monitoring bladder and bowel function, maintaining proper nutrition, preventing broken bones, promoting healthy growth and development, and encouraging activity and mobility. Many children with spina bifida have non-surgical treatments as well, such as positional aides to help the child sit and stand, physical therapy, and bracing and splints usually of the lower extremities.

Parents of children with spina bifida experience an array of emotions, including grief, fear, anxiety, and stress. Spina bifida impacts not only the affected child but the entire family. Groups and networks of other families affected by spina bifida can provide valuable support. Parents may need to be active in ensuring that their child receives the early intervention and educational services available in their community. Each state has programs to encourage healthy development in children with special needs.

Finally, parents should remember that most children with spina bifida live productive and happy lives. For the most part, children with spina bifida have average or above-average intelligence. Many of these children can go on to higher education, have active careers, and live self-sufficiently. It is important for parents to encourage strong self esteem in their child and to foster independent living skills.

Resources

Books

Behrman, Richard E., Robert M. Kliegman, and Hal B. Jenson, eds. Nelson Textbook of Pediatrics, 16th ed. Philadelphia: W. B. Saunders, 2000.

Sutton, Amy L. Back and Neck Sourcebook: Basic ConsumerHealth Information. Detroit, MI: Omnigraphics, 2004.

Organizations

March of Dimes Birth Defects Foundation. 1275 Mamaroneck Ave., White Plains, NY 10605. Web site: www.modimes.org.

National Birth Defects Prevention Network. Web site: www.nbdpn.org.

Shriners Hospitals for Children. International Shrine Headquarters, 2900 Rocky Point Dr., Tampa, FL 33607–1460. Web site: www.shrinershq.org.

Spina Bifida Association of America. 4590 MacArthur Blvd. NW, Suite 250, Washington, DC 20007–4226. Web site: www.sbaa.org.

[Article by: Roger E. Stevenson Deborah L. Nurmi, MS]


Dictionary of Cultural Literacy: Health:

spina bifida

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A congenital condition that involves an imperfectly closed spinal column, often resulting in neurological disorders.

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categories related to 'spina bifida'

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Wikipedia on Answers.com:

Spina bifida

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Spina bifida
Classification and external resources
ICD-10 Q05, Q76.0
ICD-9 741, 756.17
OMIM 182940
DiseasesDB 12306
eMedicine orthoped/557
MeSH C10.500.680.800

Spina bifida (Latin: "split spine") is a developmental congenital disorder caused by the incomplete closing of the embryonic neural tube. Some vertebrae overlying the spinal cord are not fully formed and remain unfused and open. If the opening is large enough, this allows a portion of the spinal cord to protrude through the opening in the bones. There may or may not be a fluid-filled sac surrounding the spinal cord. Other neural tube defects include anencephaly, a condition in which the portion of the neural tube that will become the cerebrum does not close, and encephalocele, which results when other parts of the brain remain unfused.

Spina bifida malformations fall into three categories: spina bifida occulta, spina bifida cystica with meningocele, and spina bifida cystica with myelomeningocele. The most common location of the malformations is the lumbar and sacral areas. Myelomeningocele is the most significant form and it is this that leads to disability in most affected individuals. The terms spina bifida and myelomeningocele are usually used interchangeably.

Spina bifida can be surgically closed after birth, but this does not restore normal function to the affected part of the spinal cord. Intrauterine surgery for spina bifida has also been performed and the safety and efficacy of this procedure is currently being investigated. The incidence of spina bifida can be decreased by up to 70% when daily folic acid supplements are taken prior to conception.

Contents

Classification

X-ray image of Spina bifida occulta in S-1
Unfused arch of C1 at CT.
Myelomeningocele in the lumbar area.
(1) External sac with cerebrospinal fluid.
(2) Spinal cord wedged between the vertebrae.

Spina bifida occulta

Occulta is Latin for "hidden". This is the mildest form of spina bifida.[1]

In occulta, the outer part of some of the vertebrae are not completely closed.[2] The split in the vertebrae is so small that the spinal cord does not protrude. The skin at the site of the lesion may be normal, or it may have some hair growing from it; there may be a dimple in the skin, or a birthmark.[3]

Many people with this type of spina bifida do not even know they have it, as the condition is asymptomatic in most cases.[3] The incidence of spina bifida occulta is approximately 10% of the population,[4] and most people are diagnosed incidentally from spinal X-rays. A systematic review of radiographic research studies found no relationship between spina bifida occulta and back pain.[5] More recent studies not included in the review support the negative findings.[6][7][8]

However, other studies suggest spina bifida occulta is not always harmless. One study found that, among patients with back pain, severity is worse if spina bifida occulta is present.[9][10]

Meningocele

The least common form of spina bifida is a posterior meningocele (or meningeal cyst).

In a posterior meningocele, the vertebrae develop normally, however the meninges are forced into the gaps between the vertebrae. As the nervous system remains undamaged, individuals with meningocele are unlikely to suffer long-term health problems, although there are reports of tethered cord. Causes of meningocele include teratoma and other tumors of the sacrococcyx and of the presacral space, and Currarino syndrome.

A meningocele may also form through dehiscences in the base of skull. These may be classified by their localisation to occipital, frontoethmoidal, or nasal. Endonasal meningoceles lie at the roof of the nasal cavity and may be mistaken for a nasal polyp. They are treated surgically. Encephalomeningoceles are classified in the same way and also contain brain tissue.

Myelomeningocele

This type of spina bifida is the most common and often results in the most severe complications.[11] In individuals with myelomeningocele, the unfused portion of the spinal column allows the spinal cord to protrude through an opening. The meningeal membranes that cover the spinal cord form a sac enclosing the spinal elements. Spina bifida with myeloschisis is the most severe form of myelomeningocele. In this type, the involved area is represented by a flattened, plate-like mass of nervous tissue with no overlying membrane. The exposure of these nerves and tissues make the baby more prone to life-threatening infections.[12][not specific enough to verify]

The protruded portion of the spinal cord and the nerves that originate at that level of the cord are damaged or not properly developed. As a result, there is usually some degree of paralysis and loss of sensation below the level of the spinal cord defect. Thus, the higher the level of the defect the more severe the associated nerve dysfunction and resultant paralysis. People may have ambulatory problems, loss of sensation, deformities of the hips, knees or feet, and loss of muscle tone. Depending on the location of the lesion, intense pain may occur originating in the lower back, and continuing down the leg to the back of the knee.[citation needed]

Signs and symptoms

Physical complications

Physical signs of spina bifida may include:

According to the Spina Bifida Association of America (SBAA), over 73 percent of people with spina bifida develop an allergy to latex, ranging from mild to life-threatening. The common use of latex in medical facilities makes this a particularly serious concern. The most common approach to avoid developing an allergy is to avoid contact with latex-containing products such as examination gloves, condoms, catheters, and many of the products used by dentists.[2]

The spinal cord lesion or the scarring due to surgery may result in a tethered spinal cord. In some individuals, this causes significant traction and stress on the spinal cord and can lead to a worsening of associated paralysis, scoliosis, back pain, and worsening bowel and/or bladder function.[15]

Neurological complications

Many individuals with spina bifida will have an associated abnormality of the cerebellum, called the Arnold Chiari II malformation. In affected individuals, the back portion of the brain is displaced from the back of the skull down into the upper neck. In approximately 90 percent of the people with myelomeningocele, hydrocephalus will also occur because the displaced cerebellum interferes with the normal flow of cerebrospinal fluid, causing an excess of the fluid to accumulate.[16] In fact, the cerebellum also tends to be smaller in individuals with spina bifida, especially for those with higher lesion levels.[14]

The corpus callosum is abnormally developed in 70-90% of individuals with spina bifida myelomeningocele; this impacts the communication processes between the left and right brain hemispheres.[17] Further, white matter tracts connecting posterior brain regions with anterior regions appear less-organized. White matter tracts between frontal regions have also been found to be impaired.[14]

Cortex abnormalities may also be present. For example, frontal regions of the brain tend to be thicker than expected while posterior and parietal regions are thinner. Thinner sections of the brain are also associated with increased cortical folding.[14] Neurons within the cortex may also be displaced.[18]

Executive function

Several studies have demonstrated difficulties with executive functions in youth with spina bifida,[19][20] with greater deficits observed in youth with shunted hydrocephalus.[21] Unlike typically developing children, youth with spina bifida do not tend to improve in their executive functioning as they grow older.[20] Specific areas of difficulty in some individuals include planning, organizing, initiating, and working memory. Problem-solving, abstraction, and visual planning may also be impaired.[22] Further, children with spina bifida may have poor cognitive flexibility. Although executive functions are often attributed to the frontal lobes of the brain, individuals with spina bifida have intact frontal lobes; therefore, other areas of the brain may be implicated.[21]

Individuals with spina bifida, especially those with shunted hydrocephalus, often have attention problems. Children with spina bifida and shunted hydrocephalus have higher rates of ADHD than typically developing children (31% vs. 17%).[19] Deficits have been observed for selective attention and focused attention, although poor motor speed may contribute to poor scores on tests of attention.[21][23] Attention deficits may be evident at a very early age, as infants with spina bifida lag behind their peers in orienting to faces.[24]

Academic skills

Individuals with spina bifida may struggle academically, especially in the subjects of mathematics and reading. In one study, 60% of children with spina bifida were diagnosed with a learning disability.[25] In addition to brain abnormalities directly related to various academic skills, achievement is likely affected by impaired attentional control and executive functioning.[18] Children with spina bifida may perform well in elementary school, but begin to struggle as academic demands increase.

Children with spina bifida are more likely than their typically-developing peers to have dyscalculia.[26] Individuals with spina bifida have demonstrated stable difficulties with arithmetic accuracy and speed, mathematical problem-solving, and general use and understanding of numbers in everyday life.[27] Mathematics difficulties may be directly related to the thinning of the parietal lobes (regions implicated in mathematical functioning) and indirectly associated with deformities of the cerebellum and midbrain that affect other functions involved in mathematical skills. Further, higher numbers of shunt revisions are associated with poorer mathematics abilities.[28] Working memory and inhibitory control deficiencies have been implicated for math difficulties,[29] although visual-spatial difficulties are not likely involved.[26] Early intervention to address mathematics difficulties and associated executive functions is crucial.[29]

Individuals with spina bifida tend to have better reading skills than mathematics skills.[28] Children and adults with spina bifida have stronger abilities in reading accuracy compared to reading comprehension.[30] Comprehension may be especially impaired for text that requires an abstract synthesis of information rather than a more literal understanding.[31] Individuals with spina bifida may have difficulty with writing due to deficits in fine motor control and working memory.[30]

Social complications

Compared to typically developing children, youth with spina bifida may have fewer friends[32] and spend less time with peers.[33] They may be more socially immature and more passive in social situations.[33] Children with spina bifida have also reported feeling less close to their friends and feel they do not receive as much emotional support from their friendships.[34] Many social difficulties tend to be stable, lasting into adulthood.[35] Youth encountering the most social difficulties tend to have lower executive functioning[36] and shunted hydrocephalus.[37] However, not all studies have found social difficulties in these youth compared with their typically developing peers.[38]

Pathophysiology

Spina bifida is caused by the failure of the neural tube to close during the first month of embryonic development (often before the mother knows she is pregnant).

Under normal circumstances, the closure of the neural tube occurs around the 23rd (rostral closure) and 27th (caudal closure) day after fertilization.[39] However, if something interferes and the tube fails to close properly, a neural tube defect will occur. Medications such as some anticonvulsants, diabetes, having a relative with spina bifida, obesity, and an increased body temperature from fever or external sources such as hot tubs and electric blankets may increase the chances of conception of a baby with a spina bifida. However, most women who give birth to babies with spina bifida have none of these risk factors, and, so, in spite of much research, it is still unknown as to what causes the majority of cases.[citation needed]

Extensive evidence from mouse strains with spina bifida indicates that there is sometimes a genetic basis for the condition. In human spina bifida, as with other human diseases such as cancer, hypertension and atherosclerosis (coronary artery disease), spina bifida likely results from the interaction of multiple genes and environmental factors.

Research has shown that lack of folic acid (folate) is a contributing factor in the pathogenesis of neural tube defects, including spina bifida. Supplementation of the mother's diet with folate can reduce the incidence of neural tube defects by about 70 percent, and can also decrease the severity of these defects when they occur.[40][41][42] It is unknown how or why folic acid has this effect.

Spina bifida does not follow direct patterns of heredity like muscular dystrophy or haemophilia. Studies show that a woman having had one child with a neural tube defect such as spina bifida has about a three percent risk of having another child with a neural tube defect. This risk can be reduced to about one percent if the woman takes high doses (4 mg/day) of folic acid before and during pregnancy. For the general population, low-dose folic acid supplements are advised (0.4 mg/day).[citation needed]

Prevention

3D Ultrasound image of the fetal spine at 21 weeks of pregnancy

There is neither a single cause of spina bifida nor any known way to prevent it entirely. However, dietary supplementation with folic acid has been shown to be helpful in preventing spina bifida. Sources of folic acid include whole grains, fortified breakfast cereals, dried beans, leaf vegetables and fruits.[43]

Folate fortification of enriched grain products has been mandatory in the United States since 1998. The U.S. Food and Drug Administration, Public Health Agency of Canada[44] and UK recommended amount of folic acid for women of childbearing age and women planning to become pregnant is at least 0.4 mg/day of folic acid from at least three months before conception, and continued for the first 12 weeks of pregnancy.[45] Women who have already had a baby with spina bifida or other type of neural tube defect, or are taking anticonvulsant medication should take a higher dose of 4–5 mg/day.[45]

Certain mutations in the gene VANGL1 are implicated as a risk factor for spina bifida: These mutations have been linked with spina bifida in some families with a history of spina bifida.[46]

Pregnancy screening

Neural tube defects can usually be detected during pregnancy by testing the mother's blood (AFP screening) or a detailed fetal ultrasound. Increased levels of maternal serum alpha-fetoprotein (MSAFP) should be followed up by two tests - an ultrasound of the fetal spine and amniocentesis of the mother's amniotic fluid (to test for alpha-fetoprotein and acetylcholinesterase). Spina bifida may be associated with other malformations as in dysmorphic syndromes, often resulting in spontaneous miscarriage. However, in the majority of cases, spina bifida is an isolated malformation.

Genetic counseling and further genetic testing, such as amniocentesis, may be offered during the pregnancy, as some neural tube defects are associated with genetic disorders such as trisomy 18. Ultrasound screening for spina bifida is partly responsible for the decline in new cases, because many pregnancies are terminated out of fear that a newborn might have a poor future quality of life. With modern medical care, the quality of life of patients has greatly improved.[39]

Treatment

There is no known cure for nerve damage due to spina bifida. To prevent further damage of the nervous tissue and to prevent infection, pediatric neurosurgeons operate to close the opening on the back. The spinal cord and its nerve roots are put back inside the spine and covered with meninges. In addition, a shunt may be surgically installed to provide a continuous drain for the excess cerebrospinal fluid produced in the brain, as happens with hydrocephalus. Shunts most commonly drain into the abdomen or chest wall. However, if spina bifida is detected during pregnancy, then open fetal surgery can be performed.[16]

In childhood

Most individuals with myelomeningocele will need periodic evaluations by a variety of specialists:[47]

  • Orthopedists to monitor growth and development of bones, muscles, and joints
  • Neurosurgeons to perform surgeries at birth and manage complications associated with tethered cord and hydrocephalus
  • Neurologists to treat and evaluate nervous system issues such as seizure disorders
  • Urologists to address kidney, bladder, and bowel dysfunction. Many will need to manage their urinary system with a program of catheterization. Bowel management programs aimed at improving elimination are also designed.
  • Opthamologists to evaluate and treat complications of the eyes.
  • Orthotists to design and customize various types of assistive technology, including braces, crutches, walkers, and wheelchairs to aid in mobility. As a general rule, the higher the level of the spina bifida defect the more severe the paralysis, but paralysis does not always occur. Thus, those with low levels may need only short leg braces, whereas those with higher levels do best with a wheelchair, and some may be able to walk unaided.
  • Physical therapists, occupational therapists, psychologists, and speech/language pathologists to aid in rehabilitative therapies and increase independent living skills.

Transition to adulthood

Although many children's hospitals feature integrated multidisciplinary teams that coordinate healthcare of youth with spina bifida, the transition to adult healthcare can be difficult because the above healthcare professionals operate independently of each other, requiring separate appointments and communicating among each other much less frequently. Healthcare professionals working with adults may also be less knowledgeable about spina bifida because it is considered a childhood chronic health condition.[48] Due to the potential difficulties of the transition, it has been suggested that adolescents with spina bifida and their families begin to prepare for the transition around ages 14-16, although this may vary depending on the adolescent's cognitive and physical abilities and his/her available family supports. The transition itself should be gradual and flexible. The adolescent's multidisciplinary treatment team may aid in the process by preparing comprehensive, up-to-date documents detailing the adolescent's medical care, including information about medications, surgery, therapies, and recommendations. A transition plan and aid in identifying adult healthcare professionals are also helpful to include in the transition process.[48]

Further complicating the transition process is the tendency for youth with spina bifida to be delayed in the development of autonomy,[49] with boys particularly at risk for slower development of independence.[50] An increased dependence on others (in particular family members) may interfere with the adolescent's self-management of health-related tasks, such as catheterization, bowel management, and taking medications.[51] As part of the transition process, it is beneficial to begin discussions at an early age about educational and vocational goals, independent living, and community involvement.[52]

Epidemiology

Spina bifida is one of the most common birth defects, with an average worldwide incidence of 1–2 cases per 1000 births, but certain populations have a significantly greater risk.

In the United States, the average incidence is 0.7 per 1000 live births. The incidence is higher on the East Coast than on the West Coast, and higher in whites (1 case per 1000 live births) than in blacks (0.1–0.4 case per 1000 live births). Immigrants from Ireland have a higher incidence of spina bifida than do nonimmigrants.[53][54] Highest rates of the defect in the USA can be found in Hispanic youth.[55]

The highest incidence rates worldwide were found in Ireland and Wales, where 3–4 cases of myelomeningocele per 1000 population have been reported during the 1970s, along with more than six cases of anencephaly (both live births and stillbirths) per 1000 population. The reported overall incidence of myelomeningocele in the British Isles was 2–3.5 cases per 1000 births.[53][54] Since then, the rate has fallen dramatically with 0.15 per 1000 live births reported in 1998,[39] though this decline is partially accounted for by the fact that some fetuses are aborted when tests show signs of spina bifida (see Pregnancy screening above).

Parents of children with spina bifida have an increased risk of having a second child with a neural tube defect.[53][54]

This condition is more likely to appear in females; the cause for this is unknown.[citation needed]

Research

Management of Myelomeningocele Study (MOMS)[56] is a phase III clinical trial to evaluate the safety and efficacy of fetal surgery to close a myelomeningocele. This involves surgically opening the pregnant mother's abdomen and uterus to operate on the fetus. This route of access to the fetus is called "open fetal surgery". Fetal skin grafts are used to cover the exposed spinal cord, to protect it from further damage caused by prolonged exposure to amniotic fluid. The fetal surgery may decrease some of the damaging effects of the spina bifida, but at some risk to both the fetus and the pregnant woman.

The MOMS trial was closed for efficacy in December 2010 based on comparing outcomes after prenatal and postnatal repair in 183 patients.

The trial demonstrated that outcomes after prenatal spina bifida treatment are improved to the degree that the benefits of the surgery outweigh the maternal risks. Results were reported in the New England Journal of Medicine by Adzick et al.[57]

To be specific, the study found that prenatal repair resulted in:

  • Reversal of the hindbrain herniation component of the Chiari II malformation
  • Reduced need for ventricular shunting (a procedure in which a thin tube is introduced into the brain’s ventricles to drain fluid and relieve hydrocephalus)
  • Reduced incidence or severity of potentially devastating neurologic effects caused by the spine’s exposure to amniotic fluid, such as impaired motor function

In contrast to the open fetal operative approach tested in the MOMS, a minimally invasive approach is currently being tested by the German Center for Fetal Surgery & Minimally Invasive Therapy at the University of Giessen, Germany.[58] This minimally invasive approach uses three small tubes (trocars) with an external diameter of 5 mm that are directly placed via small needle punctures through the maternal abdominal wall into the uterine cavity. Via this route, the unborn can be postured and its spina bifida defect be closed using small instruments. In contrast to open fetal surgery for spina bifida, the fetoscopic approach results in less trauma to the mother as large incisions of her abdomen and uterus are not required. Early results indicate that the approach may maintain the fetal muscular and sensory function that is still present at the time of fetal surgery, regardless of lesion height.

Although fetoscopic techniques that involve making multiple puncture wounds in the uterus are theoretically appealing to potentially mitigate maternal morbidity, clinical reports on their use are limited and the results have been disappointing, primarily because of uterine membrane problems leading to premature birth 3 to 6 weeks after the procedure and delivery before 30 weeks of gestation.[59] As compared with the open fetal surgery technique, fetoscopic repair of myelomeningocele has resulted in higher rates of fetal death, premature rupture of membranes, chorioamnionitis, oligohydramnios, premature delivery, and persistent hindbrain herniation.[60][61][62] If the problems of membrane rupture associated with fetoscopy can be solved, this minimally invasive approach to repairing myelomeningocele before birth should be tested clinically.

Notable people

Notable people with spina bifida include:

References

  1. ^ "What Is Spina Bifida?". ASBAH. http://www.asbah.org/Spina+Bifida/informationsheets/whatisspinabifida.htm. Retrieved 2009-02-14. 
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