Sickle-Cell Disease

well I'm 18 yrs old and i have sickle cell trait. i can tell you that there are not that many here are some:

-don't exercise for a prolonged time i did this a couple of times and when i stopped to catch my breath i felt very dizzy like if i was going to faint

-make sure your hydrated all day to ensure you red blood cells are constantly moving

-and last you will probably have some acute migraines or have tiny headaches sometime out of nowhere

i hope my advice helps you better understand make sure to get your partner tested

It used to put a life expectancy on those who have it. The age used to be 21. These days people are surviving longer and longer with it. It really can be managed, if the person takes care of themselves. My boyfriend has it and is 34 years old.

1.It is particularly common among people whose ancestors come from sub-Saharan Africa; Spanish-speaking regions (South America, Cuba, Central America); Saudi Arabia; India; and Mediterranean countries such as Turkey, Greece, and Italy. In the Unites States, it affects around 72,000 people, most of whose ancestors come from Africa. The disease occurs in about 1 in every 500 African-American births and 1 in every 1000 to 1400 Hispanic-American births. About 2 million Americans, or 1 in 12 African Americans, carry the sickle cell trait.

The below text is partially incorrect:

According to pubmed (a government run medical website) only 2 white people have been diagnosed with sickle cell. It was caused by a random mutation in their genes. For a white person to get sickle cell they must have a 1 in a trillion genetic mutation because there is no genetic history of sickle cell in white people. No genetic history of sickle cell means that it can not be inherited, it can only come from a mutation. Black people have much higher odds of having sickle cell because there is a genetic history of sickle cell in Africans. This means that it can be inherited from the parents. Sickle cell originated in three independent blood lines in Africa and one blood line in India 70,000-150,000 years ago. If you have sickle cell it means you are a descendent of one of these blood lines.

2. i am white and having sickle cell trait and alot off people around me having sickle cell disease

ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage

Basically, sickle cell anemia means that some of the red blood cells of the person with the disease are not the right shape, instead of being bowl shaped, they are half moon shaped. This means that they can't carry oxygen around the body as well as a person without the condition. As the sickle cells are not only the wrong shape, but also quite rigid, they can block the blood capillaries, so that tissues in the body become starved of oxygen (ischemic). The blockages can vary loads in severity/frequency etc, and they can end up causing a stroke or heart attack if blocking a blood vessel to the brain or heart. One of the organs that is really badly affected by this is the spleen. It has really narrow blood vessels leading to it, so can get starved of oxygen badly and frequently. Normally this means that people with sickle cell anemia do not have a working spleen by the end of childhood, so are at risk of infections. People with sickle cell anemia tend to have more red blood cells than people without the condition as their body over compensates for the red blood cells.

platelets are carried in our body system in the blood along with Red blood cells, white blood cells and plasma, these platelets are very important for body, if you sustain a cut on yourself these platelets will cause the blood to make a clot. This is where you have scabs where the blood has clotted to stop blood escaping from the body. This is important now that if you have a small amount of platelets you can be diagnosed with an illness called haemophilia this is when you blood doesn't clot. So if you cut your self you will be sent to hospital to have platelets injected to cause the bleeding to stop as you will continuely bleed.

yes it can skip a generation, since it is a Mendel inheritance. and it is a reccesive trait. therefore offspring's can have two unaffected parents but chances are both parents might be carriers

Well, its a genetic disorder that is most common among African Americans. It is when red blood cells are C shaped. It's an example of a problem

It is an example of pleiotropy.

diagnosis would have to be for any person or persons grieving. maybe dysfunctional grieving/ or/ anxiety related to recent family death

It depends on what type of anemia the patient may have.

Iron deficiency anemia would have a nursing diagnosis of Imbalanced Nurtition: less than body requirements.

If anemia is caused by acute hemorrhage, restoring blood volume is the highest priority.

Activity Intolerance - inadequate oxygen delivery to the tissues can lead to weakness, fatigue, and shortness of breath with activity.

Folic acid deficiency anemia may have a diagnosis of Impaired oral mucous membranes r/t fluid deficit (folic acid deficiency anemia has gastrointestinal manifestations of glossitis, cheilosis and diarrhea).

decrease cardiac output

Black people have a genetic predisposition to sickle cell anemia. Recently there has been progress made in curing this horrible disease.

Sickle-cell disease, usually presenting in childhood, occurs more commonly in people (or their descendants) from parts of tropical and sub-tropical regions where malaria is or was common. One-third of all indigenous inhabitants of Sub-Saharan Africa carry the gene, because in areas where malaria is common, there is a survival value in carrying only a single sickle-cell gene . Those with only one of the two alleles of the sickle-cell disease are more resistant to malaria, since the infestation of the malaria plasmodium is halted by the sickling of the cells which it infests.

The prevalence of the disease in the United States is approximately 1 in 5,000, mostly affecting African Americans, according to the National Institutes of Health.

I'm guessing you meant sickle cell anemia. You already said that it's recessive, which means that both parents have to be carriers for it to be passed on to their children. If both parents carry the gene, then there is a 1 in 4 chance of having an affected offspring, 2 in 4 chances of having offsprings which carry the disease, and 1 in 4 of the child being unaffected (check out how to draw a punnet square). If one parent is a carrier and the other one is healthy, then you have a 50% chance of having an offspring who carries the disease, but none of your offsprings will be affected. Hope this helps

If both parents have sickle cell trait, they each carry one normal allele (A) and one sickle cell allele (S). The possible genotypes for their children are AA (normal), AS (carrier), and SS (sickle cell disease), with a probability of 25% for each genotype. Therefore, the chance of having three children who are homozygous for normal red blood cells (AA) is ( (0.25)^3 ), which equals 1/64, or about 1.56%.

Sickle cell disease is important because it is a genetic disorder that affects the shape of red blood cells, leading to pain, anemia, and organ damage. It predominantly affects people of African, Mediterranean, Middle Eastern, or Indian descent. Early diagnosis and proper management are crucial to prevent complications and improve quality of life for individuals with sickle cell disease.

SS,Ss

Sickle cell anemia was first described in the medical literature in 1910 by Dr. James B. Herrick, who identified the unique sickle-shaped red blood cells in a patient of African descent. The genetic basis of the disease was later elucidated by Dr. Linus Pauling in the 1940s.

malaria

People who inherit one sickle cell gene are said to have sickle cell trait. This means they carry the gene but do not typically have symptoms of sickle cell disease. It is important for individuals with sickle cell trait to be aware of their status for proper medical management and genetic counseling.

Sickle cell anemia is a disease passed down through families in which red blood cells are an abnormal crescent shape. Sickle cell anemia is a disorder of the erythrocytes (Red blood cells). It causes their normal biconcave shape to be replaced with that of a sickle or crescent. People with this disease have problems transporting oxygen throughout their bodies, as a result of this, they become fatigued easily and have rapid heart rates even when resting.

It has to do with your genitic make up. You don't have sickle cell anemia because you only have 1 of the traits on your beta hemoglobin gene. People with sickle cell anemia have two.Most of the time peolple with sickle cell trait display much milder symptoms.

It is more prevolent in African Americans and woman should be monitored during pregnancy.

Yes, if the sickle cell trait were a dominant trait, it could still be a form of balanced polymorphism. In a dominant scenario, individuals with one copy of the allele would express the trait. In this case, heterozygous individuals would have the sickle cell trait, potentially providing a selective advantage against malaria, similar to how carriers of the recessive trait do in the current situation.

An example pedigree chart for sickle-cell anaemia can be found using the related link below.

Individuals shaded black have the disease, individuals that are not shaded are unaffected, and individuals that are carriers are shown with diagonal lines (they are often shown with a single dot in the centre of their shape).