Sickle-Cell Disease

1 have o good hygiene

2 when brushing your teeth scrape your tongue gently too

3 eat healthy

4 don't sip too hot soup/liquid

5 don't put sharp objects in your mouth

6 don't lick dirty objects to avoid infection

7 avoid too spicy food

8 always gargle or rinse your mouth after eating

9 don't swallow inedible object esp chemicals

10 avoid tongue piercing as much as possible

Cannot carry normal levels of oxygen to cells :) *NovaNet*

Sickle cell disease is an inherited blood disorder that affects red blood cells.

The 11th pair of chromosomes contains a gene responsible for normal hemoglobin production. A mutation or error in this gene is what causes sickle cell disease.

The sickle cells can block the flow of blood through vessels resulting in lung tissue damage (acute chest syndrome), pain episodes (arms, legs, chest and abdomen), stroke and priapism (painful prolonged erection). It also causes damage to most organs including the spleen, kidneys and liver. Damage to the spleen makes sickle cell disease patients, especially young children, easily overwhelmed by certain bacterial infections. All The above mentiond causes will appeare if the patient not get proper medication

Yes, Sickle Cell-Anemia is a genetic condition that is passed down from one generation to the other.

Sickle Cell Anemia is Autosomal Recessive. It arises from a mutation on the beta-globin gene of chromosome 11.

Because Sickle Cell Anemia is an example of incomplete dominance, a person has the disease if they have two mutated beta-globin genes but only has the trait (is a carrier) if they have only one mutated beta-globin gene.

Hemoglobin molecules are mutated, thus giving the red blood cells an abnormal, rigid shape.

No. It is a generally found only in the African/ American community.

you should increase your water intake as much as you can to prevent dehydration and take pain killer in a crisis and take amoxil to prevent infection with supplemental folic acid to increase RBC production

and there is new drug called hydroxyurea which increase hemoglobin F which characterized by high affinity to oxygen which might prevent the crisis or make them milder...

Because individuals who inherit the gene from only one parent produce red blood cells which are distorted. This distortion makes the cells unpalatable to malaria parasites, without seriously harming the individual. This tends to protect against malaria and that protection causes selection for this allele. Individuals who get the sickle cell gene from both parents suffer serious distortion of the red blood cells. This protects against malaria, but also reduces the oxygen-carrying capacity of the red cells to a dangerous degree. This causes a disease called sickle-cell anaemia, which causes selection against the gene. In malarial regions a balance is established. When a population with sickle cell alleles moves to an area with effectively no malaria present, the sickle cell alleles are steadily selected against. This shifts the balance steadily towards low levels.

Sickle cell anemia is an inherited disease. People who have the disease inherit two copies of the sickle cell gene-one from each parent. The sickle cell gene causes the body to make abnormal hemoglobin. Hemoglobin is the iron-rich protein that gives blood its red color and carries oxygen from the lungs to the rest of the body. In sickle cell anemia, the hemoglobin sticks together when it delivers oxygen to the body's tissues. These clumps of hemoglobin are like liquid fibers. They cause the red blood cells to become stiff and shaped like a sickle, or "C." The sickled red blood cells tend to stick together and get caught in the blood vessels. (Other cells also may play a role in this process.) Two copies of the sickle cell gene are needed for the body to make the abnormal hemoglobin found in sickle cell anemia.

AR 40-501

Chapter 2

Physical Standards for Enlistment, Appointment, and Induction

2-4. Blood and blood-forming tissue diseases

a. Anemia. Current hereditary or acquired anemia, which has not been corrected with therapy before appointment or induction, is disqualifying. For the purposes of this regulation, anemia is defined as hemoglobin of less than 13.5 for males and less than 12 for females. The following ICD-9 codes are used for diagnosed anemia: hereditary hemolytic anemia (282), sickle cell disease (282.6), acquired hemolytic anemia (283), aplastic anemia (284), or unspecified anemias (285).

I have sickle cell anemia and I desire to join to military too. You can always ask the recruiter for more questions.

Priapism is caused by leukemia, sickle cell disease, spinal cord injury, a rare side effect of the anti-depressant trazodone (Desyrel) or an overdose of self-injected chemicals to treat impotence.

well I'm 18 yrs old and i have sickle cell trait. i can tell you that there are not that many here are some:

-don't exercise for a prolonged time i did this a couple of times and when i stopped to catch my breath i felt very dizzy like if i was going to faint

-make sure your hydrated all day to ensure you red blood cells are constantly moving

-and last you will probably have some acute migraines or have tiny headaches sometime out of nowhere

i hope my advice helps you better understand make sure to get your partner tested

It used to put a life expectancy on those who have it. The age used to be 21. These days people are surviving longer and longer with it. It really can be managed, if the person takes care of themselves. My boyfriend has it and is 34 years old.

1.It is particularly common among people whose ancestors come from sub-Saharan Africa; Spanish-speaking regions (South America, Cuba, Central America); Saudi Arabia; India; and Mediterranean countries such as Turkey, Greece, and Italy. In the Unites States, it affects around 72,000 people, most of whose ancestors come from Africa. The disease occurs in about 1 in every 500 African-American births and 1 in every 1000 to 1400 Hispanic-American births. About 2 million Americans, or 1 in 12 African Americans, carry the sickle cell trait.

The below text is partially incorrect:

According to pubmed (a government run medical website) only 2 white people have been diagnosed with sickle cell. It was caused by a random mutation in their genes. For a white person to get sickle cell they must have a 1 in a trillion genetic mutation because there is no genetic history of sickle cell in white people. No genetic history of sickle cell means that it can not be inherited, it can only come from a mutation. Black people have much higher odds of having sickle cell because there is a genetic history of sickle cell in Africans. This means that it can be inherited from the parents. Sickle cell originated in three independent blood lines in Africa and one blood line in India 70,000-150,000 years ago. If you have sickle cell it means you are a descendent of one of these blood lines.

2. i am white and having sickle cell trait and alot off people around me having sickle cell disease

ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage ulcers, jaundice, or yellowing of the skin, eyes, and mouth, eye damage

Basically, sickle cell anemia means that some of the red blood cells of the person with the disease are not the right shape, instead of being bowl shaped, they are half moon shaped. This means that they can't carry oxygen around the body as well as a person without the condition. As the sickle cells are not only the wrong shape, but also quite rigid, they can block the blood capillaries, so that tissues in the body become starved of oxygen (ischemic). The blockages can vary loads in severity/frequency etc, and they can end up causing a stroke or heart attack if blocking a blood vessel to the brain or heart. One of the organs that is really badly affected by this is the spleen. It has really narrow blood vessels leading to it, so can get starved of oxygen badly and frequently. Normally this means that people with sickle cell anemia do not have a working spleen by the end of childhood, so are at risk of infections. People with sickle cell anemia tend to have more red blood cells than people without the condition as their body over compensates for the red blood cells.

platelets are carried in our body system in the blood along with Red blood cells, white blood cells and plasma, these platelets are very important for body, if you sustain a cut on yourself these platelets will cause the blood to make a clot. This is where you have scabs where the blood has clotted to stop blood escaping from the body. This is important now that if you have a small amount of platelets you can be diagnosed with an illness called haemophilia this is when you blood doesn't clot. So if you cut your self you will be sent to hospital to have platelets injected to cause the bleeding to stop as you will continuely bleed.

yes it can skip a generation, since it is a Mendel inheritance. and it is a reccesive trait. therefore offspring's can have two unaffected parents but chances are both parents might be carriers

Well, its a genetic disorder that is most common among African Americans. It is when red blood cells are C shaped. It's an example of a problem

It is an example of pleiotropy.

diagnosis would have to be for any person or persons grieving. maybe dysfunctional grieving/ or/ anxiety related to recent family death