Aspirin

It is possible to extract salicylic acid, a precursor to aspirin, from certain plants like willow bark; however, most aspirin is now synthesized in a laboratory setting. Harvesting aspirin from plants is not common practice due to efficiency and cost considerations.

If you have a skin reaction to salicylic acid, stop using the product immediately and rinse your skin thoroughly with water. Apply a gentle, soothing moisturizer to help calm the irritation and consider seeing a dermatologist for further guidance and treatment.

Patients with achlorhydria have low or absent stomach acid, which is needed to break down aspirin for absorption. Without stomach acid, aspirin can dissolve quickly in the stomach and be absorbed more rapidly into the bloodstream, potentially leading to increased systemic effects and side effects.

Yes it will be weakly acidic. Aspirin's scientific name is acetylsalicylic acid, with a pKa of 3.5. This would mean that for a solution of 0.1 M aspirin, the pH of the solution would be approximately 2.26.

Givens for question above: If the aspirin tablet is 0.4635g. it was titrated with 18.23mL of 0.1000M NaOH to neutralize. Then 33mL of NaOH was added to hydrolyze. then it was back titrated w/13.59mL HCl. what is mass of acetylsalicylic acid? what is the percent w/w?

Caffeine > Acetaminophen > Ibuprofen > ASA

Actually ASA is more polar than Ibuprofen. In ethanol ASA rf value is around .7 and Ibuprofen is around .77.

Should be Caffeine > Acetaminophen > ASA > Ibuprofen

Rf in ethanol Caffeine < Acetaminophen < ASA < Ibuprofen

Aspirin is classified under antipyretic (decreases temperature) and a non-opioid analgesic (reduces pain). It can also be used as a anti-thrombolytic (anti-clotting agent- 81mg) It makes the platelets (blood component responsible for clotting) slippery so they don't stick to anything in the vessels, which decreases your risk of DVT (blood clots).

Vacuum filtration was used instead of gravity filtration in the isolation of aspirin to speed up the filtration process by applying negative pressure to draw the solvent through the filter paper more quickly. This helps to separate the solid product from the solvent more efficiently and saves time in the isolation process.

Phosphoric acid is used in the synthesis of aspirin as a catalyst to facilitate the esterification reaction between salicylic acid and acetic anhydride. It helps increase the reaction rate and yield of aspirin.

Chromatography could be used to separate the components of the reaction mixture and identify if aspirin is present by comparing the retention time of the product to that of a known aspirin standard. If the retention time matches, it indicates the presence of aspirin in the reaction mixture. Additionally, chromatography can help determine the purity of the aspirin product by analyzing the intensity of the peak corresponding to aspirin.

Maintaining the temperature at 90 degrees C in the synthesis of aspirin helps to achieve optimal reaction kinetics, ensuring the reaction proceeds at a suitable rate. This temperature also promotes the formation of the desired product while minimizing the formation of unwanted byproducts.

see there http://homechemistry.blogspot.com/2008/04/aspirin-lab.html Lesson: Acid-catalyzed hydrolysis of acetylsalicylic acid to salicylic acid and acetic acid What Happened: We dissolved the active ingredient of aspirin in water, separated it from the binder, then purified the drug using sulfuric acid as a catalyst. The World of Chemistry video series, which you can watch online at Annenberg Media, has been serving as our spine lately. We were up to the episode on catalysts this week, so I found a demonstration from The Joy of Chemistry (actually from the chapter on organic chemistry) which used dilute sulfuric acid (sold as aquarium pH lowering solution) as a catalyst to purify aspirin. FYI, another example of a catalyst at work were the pineapple enzymes we used to dissolve Jello. According to Wikipedia, the end product of this demonstration, salicylic acid, is what aspirin metabolizes into in the liver. Its name comes from the Latin word for the willow tree, Salix, from whose bark it can be obtained. Interestingly, it can also be derived from methyl salicylate (oil of wintergreen). In 1897, Felix Hoffmann, a chemist at Friedrich Bayer & Co., obtained acetylsalicylic acid by a reaction of salicylic acid and acetic anhydride; this is the basis for Bayer's claims to the discovery of aspirin. Materials: Safety glasses Rubber gloves 10-15 aspirin (plain or buffered) ½ cup (120 ml) rubbing alcohol (70% isopropyl) 2-4 large glass containers (we used a Pyrex bowl and old honey jars and canning jars) Coffee filters and rubber bands Sturdy plastic spoon Aquarium lowering solution (dilute sulfuric acid) Pipette or straw =>>>>>>>>>>>>>>>>>>>> 1.Place aspirin in glass. 2.Pour in alcohol, a little more than needed to cover the aspirin. 3.Heat the glass in the microwave on 50% power for 30 seconds until warm but not boiling. The acetylsalicyclic acid will dissolve in the alcohol, leaving the starch binder. 4.Gently crush remaining residue with spoon to extract as much acid as possible. Let sit 15-30 minutes. 5.Take coffee filter and spread it over top of second glass. Push it down slightly so it resembles a funnel. Secure with rubber band. 6.Carefully pour the solution through the filter. The liquid that drips through is called the “mother liquor.” The acetylsalicylic acid has dissolved in the water. What's left on the filter is the starch binder that holds the drug in the pill shape. 7.Wearing gloves, dispose of coffee filter. Don’t touch the wet part. 8.Run a small stream of cold tap water. Take the glass with the mother liquor and add water until it is about ¾ full. Small white flakes of acid should begin falling out of solution. Let sit for a couple hours. 9.Set up another filter on another glass. Pour mixture through filter to separate out the crystals. 10.Filter 2-3 times if needed, letting solution sit for 1-2 hours in between. 11.Allow to dry overnight, away from breezes. The crystals will become fluffy. 12.Take ¼ of wet or dry crystals and put into glass. Add aquarium solution dropwise with a pipette or straw until the entire sample is completely covered. The sulfuric acid is the catalyst and remains at the end, so be careful with the liquid. 13.Heat the mixture in the microwave for no more than 15 seconds at 50% power. It may start to steam immediately. 14.Remove glass. You should smell vinegar (acetic acid) evaporating. If not, wave your hand over the glass to waft the fumes towards your nose. The sludge that remains is salicylic acid. 15.Dispose of solids in the trash and liquids in the toilet. NOTES: We ended up doing the demonstration twice -- although, as it turned out, we probably didn't need to -- because the shopping list at the beginning of the book didn't specify that the alcohol needed was 70% concentration. I found an old bottle of the right concentration, and we did everything over. However, we discovered that letting the first solution sit and filtering it several more times yielded enough crystals to do the demonstration. In the end, we had twice as much acetylsalicylic acid as we needed. We probably used too much in the final step (as well as too much sulfuric acid, which I tried to pour slowly out of the bottle instead of using a pipette) because when we put it in the microwave, it immediately started steaming! I turned it off a few seconds short of 15 and the vinegar smell was overwhelming.

The rock in question is oil shale, from which aspirin, nylon, and perfume can be obtained as by-products through a process called retorting. Oil shale is heated to release kerogen, a precursor to oil, which can then be further processed to produce various products including aspirin, nylon, and perfume.

The ingredients needed to produce aspirin are salicylic acid and acetic anhydride. Acetic acid is also produced as a byproduct during the chemical reaction.

Compound, as it is a single substance, held together with chemical bonds.

Do not be confused with alcohols nor ketones when seeing the -OH and the =O bonded. They each are really parts of either:
- the carboxylic acid group (-COOH)
- the ester link (from neighbour carbon along the ring)


Likewise, double-bonds you see constitute the benzene (aromatic) ring:
- a functional group in itself
- they are not the normal alkene double bonds
- would actually best be represented by a circle inside the ring,
- not double lines for each of 3 double bonds, as resonance occurs in benzene rings.


Therefore, aspirin (or acetylsalicylic acid) contains:
- aromatic ring
- carboxylic acid group
- ester group
and can be regarded as an acid (i.e. acetylsalicylic acid)
or the acetate ester of salicylic acid :-)


so aspirin is (if choosing from your options):
- not an alkene, nor a ketone, nor an alcohol.
- we are left with a carboxylic acid
BUT we usually only regard aspirin as an acetate ester, or a derivative of salicylic acid,
so you wouldn't generally hear one calling aspirin a carboxylic acid :-)


I hope I cleared things up a bit :-)
Cheers.

Germany is credited for inventing aspirin however aspirin had already been made in France but had not been given the name aspirin and the French Chemist that made it did not market it. So 46 years later the idea was rediscovered in Germany and the Germans gave the compound the name aspirin and marketed it with the Bayer company.

It depends on the reason for use:

As a long term anticoagulant or preventative measure for heart disease the standard dose is 81mg per day. This is a baby aspirin dose. This will vary depending on the medical professionals evaluation of the patient. And you should be evaluated first. Research during 2013-2014 showed that daily aspirin may not help all patients and can create harmful effects.

As a painkiller for adults the recommended dose is 1-2 tablets every 4-6 hours which is 275-300mg. Not exceeding 3 doses per day. Do not use if you are on any other anti-coagulants such as Warfarin, or have had a stomach ulcer in the past 12 months. For people who smoke and drink, the chances of stomach bleeding, a rare side effect, is increased.

For Children, it is half that dose MAXIMUM. Do not use to treat symptoms of chicken pox as it may cause a fatal side effect called Reye's syndrome, a rare but possible side effect of Aspirin.

Pregnancy:

Aspirin should NOT TO BE USED DURING PREGNANCY AS HIS MAY CAUSE FETAL DAMAGE, ESPECIALLY IN THE LAST TRIMESTER.

No. Aspirin prevents the synthesis of Thromboxane A2 which induces platelet aggregation (formation of a clot) and platelet release reaction. Aspirin inhibits this platelet aggregation for the life of the platelets, which is between 7-10 days. The cool thing with aspirin is that it thins your blood, the bad thing is that it thins your blood and if you want to stop taking aspirin (for any reason, even before surgery) you have a 3x increase of stroke or heart attack for 8-10 days because of its rebound effect. Aspirin is a light-weight compared to Heparin or Coumadin, but Heparin is easily reversed with Protamine-sulfate solution 1% and Coumadin with Vitamin K - something to think about. Maybe one day a drug will be created to reactivate Thromboxane A2 synthesis, but not yet. Trust your PA-C's.

No, it has acetaminophen. Do not take multipli products containing acetaminophen without checking with your doctor as this could result in serious liver problems

Sprite wil rust nails. Almost all are fastacting.The reson it rust is the carbonation.Witch will slowley brake down nails.My chiled did a project she discovered that sprite will rust fastes.

Buffered aspirin contains an additional ingredient, usually calcium carbonate or magnesium oxide, that helps to neutralize stomach acid and reduce irritation to the stomach lining. This makes buffered aspirin less likely to cause gastrointestinal side effects such as irritation, ulcers, or bleeding compared to regular aspirin.

You place the reaction mixture in an ice bath to complete crystallisation because asoirin olecules are quite big and are insoluble in the water, hence forming crystals while the other rmaining substances stay dissolved in water (salicylic acid and acetic acid)