Aspirin

Chromatography could be used to separate the components of the reaction mixture and identify if aspirin is present by comparing the retention time of the product to that of a known aspirin standard. If the retention time matches, it indicates the presence of aspirin in the reaction mixture. Additionally, chromatography can help determine the purity of the aspirin product by analyzing the intensity of the peak corresponding to aspirin.

Maintaining the temperature at 90 degrees C in the synthesis of aspirin helps to achieve optimal reaction kinetics, ensuring the reaction proceeds at a suitable rate. This temperature also promotes the formation of the desired product while minimizing the formation of unwanted byproducts.

see there http://homechemistry.blogspot.com/2008/04/aspirin-lab.html Lesson: Acid-catalyzed hydrolysis of acetylsalicylic acid to salicylic acid and acetic acid What Happened: We dissolved the active ingredient of aspirin in water, separated it from the binder, then purified the drug using sulfuric acid as a catalyst. The World of Chemistry video series, which you can watch online at Annenberg Media, has been serving as our spine lately. We were up to the episode on catalysts this week, so I found a demonstration from The Joy of Chemistry (actually from the chapter on organic chemistry) which used dilute sulfuric acid (sold as aquarium pH lowering solution) as a catalyst to purify aspirin. FYI, another example of a catalyst at work were the pineapple enzymes we used to dissolve Jello. According to Wikipedia, the end product of this demonstration, salicylic acid, is what aspirin metabolizes into in the liver. Its name comes from the Latin word for the willow tree, Salix, from whose bark it can be obtained. Interestingly, it can also be derived from methyl salicylate (oil of wintergreen). In 1897, Felix Hoffmann, a chemist at Friedrich Bayer & Co., obtained acetylsalicylic acid by a reaction of salicylic acid and acetic anhydride; this is the basis for Bayer's claims to the discovery of aspirin. Materials: Safety glasses Rubber gloves 10-15 aspirin (plain or buffered) ½ cup (120 ml) rubbing alcohol (70% isopropyl) 2-4 large glass containers (we used a Pyrex bowl and old honey jars and canning jars) Coffee filters and rubber bands Sturdy plastic spoon Aquarium lowering solution (dilute sulfuric acid) Pipette or straw =>>>>>>>>>>>>>>>>>>>> 1.Place aspirin in glass. 2.Pour in alcohol, a little more than needed to cover the aspirin. 3.Heat the glass in the microwave on 50% power for 30 seconds until warm but not boiling. The acetylsalicyclic acid will dissolve in the alcohol, leaving the starch binder. 4.Gently crush remaining residue with spoon to extract as much acid as possible. Let sit 15-30 minutes. 5.Take coffee filter and spread it over top of second glass. Push it down slightly so it resembles a funnel. Secure with rubber band. 6.Carefully pour the solution through the filter. The liquid that drips through is called the “mother liquor.” The acetylsalicylic acid has dissolved in the water. What's left on the filter is the starch binder that holds the drug in the pill shape. 7.Wearing gloves, dispose of coffee filter. Don’t touch the wet part. 8.Run a small stream of cold tap water. Take the glass with the mother liquor and add water until it is about ¾ full. Small white flakes of acid should begin falling out of solution. Let sit for a couple hours. 9.Set up another filter on another glass. Pour mixture through filter to separate out the crystals. 10.Filter 2-3 times if needed, letting solution sit for 1-2 hours in between. 11.Allow to dry overnight, away from breezes. The crystals will become fluffy. 12.Take ¼ of wet or dry crystals and put into glass. Add aquarium solution dropwise with a pipette or straw until the entire sample is completely covered. The sulfuric acid is the catalyst and remains at the end, so be careful with the liquid. 13.Heat the mixture in the microwave for no more than 15 seconds at 50% power. It may start to steam immediately. 14.Remove glass. You should smell vinegar (acetic acid) evaporating. If not, wave your hand over the glass to waft the fumes towards your nose. The sludge that remains is salicylic acid. 15.Dispose of solids in the trash and liquids in the toilet. NOTES: We ended up doing the demonstration twice -- although, as it turned out, we probably didn't need to -- because the shopping list at the beginning of the book didn't specify that the alcohol needed was 70% concentration. I found an old bottle of the right concentration, and we did everything over. However, we discovered that letting the first solution sit and filtering it several more times yielded enough crystals to do the demonstration. In the end, we had twice as much acetylsalicylic acid as we needed. We probably used too much in the final step (as well as too much sulfuric acid, which I tried to pour slowly out of the bottle instead of using a pipette) because when we put it in the microwave, it immediately started steaming! I turned it off a few seconds short of 15 and the vinegar smell was overwhelming.

The rock in question is oil shale, from which aspirin, nylon, and perfume can be obtained as by-products through a process called retorting. Oil shale is heated to release kerogen, a precursor to oil, which can then be further processed to produce various products including aspirin, nylon, and perfume.

The ingredients needed to produce aspirin are salicylic acid and acetic anhydride. Acetic acid is also produced as a byproduct during the chemical reaction.

Compound, as it is a single substance, held together with chemical bonds.

Do not be confused with alcohols nor ketones when seeing the -OH and the =O bonded. They each are really parts of either:
- the carboxylic acid group (-COOH)
- the ester link (from neighbour carbon along the ring)


Likewise, double-bonds you see constitute the benzene (aromatic) ring:
- a functional group in itself
- they are not the normal alkene double bonds
- would actually best be represented by a circle inside the ring,
- not double lines for each of 3 double bonds, as resonance occurs in benzene rings.


Therefore, aspirin (or acetylsalicylic acid) contains:
- aromatic ring
- carboxylic acid group
- ester group
and can be regarded as an acid (i.e. acetylsalicylic acid)
or the acetate ester of salicylic acid :-)


so aspirin is (if choosing from your options):
- not an alkene, nor a ketone, nor an alcohol.
- we are left with a carboxylic acid
BUT we usually only regard aspirin as an acetate ester, or a derivative of salicylic acid,
so you wouldn't generally hear one calling aspirin a carboxylic acid :-)


I hope I cleared things up a bit :-)
Cheers.

Germany is credited for inventing aspirin however aspirin had already been made in France but had not been given the name aspirin and the French Chemist that made it did not market it. So 46 years later the idea was rediscovered in Germany and the Germans gave the compound the name aspirin and marketed it with the Bayer company.

It depends on the reason for use:

As a long term anticoagulant or preventative measure for heart disease the standard dose is 81mg per day. This is a baby aspirin dose. This will vary depending on the medical professionals evaluation of the patient. And you should be evaluated first. Research during 2013-2014 showed that daily aspirin may not help all patients and can create harmful effects.

As a painkiller for adults the recommended dose is 1-2 tablets every 4-6 hours which is 275-300mg. Not exceeding 3 doses per day. Do not use if you are on any other anti-coagulants such as Warfarin, or have had a stomach ulcer in the past 12 months. For people who smoke and drink, the chances of stomach bleeding, a rare side effect, is increased.

For Children, it is half that dose MAXIMUM. Do not use to treat symptoms of chicken pox as it may cause a fatal side effect called Reye's syndrome, a rare but possible side effect of Aspirin.

Pregnancy:

Aspirin should NOT TO BE USED DURING PREGNANCY AS HIS MAY CAUSE FETAL DAMAGE, ESPECIALLY IN THE LAST TRIMESTER.

No. Aspirin prevents the synthesis of Thromboxane A2 which induces platelet aggregation (formation of a clot) and platelet release reaction. Aspirin inhibits this platelet aggregation for the life of the platelets, which is between 7-10 days. The cool thing with aspirin is that it thins your blood, the bad thing is that it thins your blood and if you want to stop taking aspirin (for any reason, even before surgery) you have a 3x increase of stroke or heart attack for 8-10 days because of its rebound effect. Aspirin is a light-weight compared to Heparin or Coumadin, but Heparin is easily reversed with Protamine-sulfate solution 1% and Coumadin with Vitamin K - something to think about. Maybe one day a drug will be created to reactivate Thromboxane A2 synthesis, but not yet. Trust your PA-C's.

No, it has acetaminophen. Do not take multipli products containing acetaminophen without checking with your doctor as this could result in serious liver problems

Sprite wil rust nails. Almost all are fastacting.The reson it rust is the carbonation.Witch will slowley brake down nails.My chiled did a project she discovered that sprite will rust fastes.

Buffered aspirin contains an additional ingredient, usually calcium carbonate or magnesium oxide, that helps to neutralize stomach acid and reduce irritation to the stomach lining. This makes buffered aspirin less likely to cause gastrointestinal side effects such as irritation, ulcers, or bleeding compared to regular aspirin.

You place the reaction mixture in an ice bath to complete crystallisation because asoirin olecules are quite big and are insoluble in the water, hence forming crystals while the other rmaining substances stay dissolved in water (salicylic acid and acetic acid)

Aspirin makes the cut flowers bloom very fast but it kills them within a few days and they end up smelling really bad. Plain water preserves the plants longer and a lot better than the little packet that comes with them (the plant food.)

Water is a polar molecule whereas aspirin has no overall charge so the two don't mix very well.

Heating the water or adding a few drops of ethanol will make it dissolve a lot faster though.

Correction:

Aspirin (2-acetoxy-benzoic acid) is a moderately strong acid. It might be called a semi-polar molecule. Ethanol is similar in this respect, and is a good solvent for aspirin.

As in all such cases, solubility is determined by the forces between the molecules in solid aspirin compared to the affinity between water and aspirin. The question has no trivial answer.

The salts of weak organic acids are usually more soluble than the acids themselves. Adding a base such as sodium hydroxide or ammonia to the water is likely to bring more aspirin into solution - but strictly speaking, the dissolved specis is not 2-acetoxy-benzoic acid, but 2-acetoxy-benzoate.

Acetylsalicylic acid, better known as aspirin, has an approximate pH of 3 to 4.

According to the particle model:

. All substances are made of tiny particles.

. The particles are attracted towards other surrounding particles.

. The particles are always moving or vibrating

. The Hotter the substance is, the faster the particles move

so when you put the aspirin in water the small particles start moving in the water and the smaller the aspirin is the faster it will disolve

Aspirin can degrade over time when exposed to room temperature, leading to decreased effectiveness. It can also potentially develop a strong vinegar-like odor, indicating breakdown of the active ingredient. It's advisable to store aspirin in a cool, dry place to maintain its potency.

The pain reliever in willow bark is Salicylic acid. If it is concentrated too much it can cause ulcers. The most common way of extracting the pain reliever is to steep the shredded bark in hot water to make a tea.

Aspirin (ASA) is a compound and is then a pure substance.

A mixture is a mix of pure substances while a pure substance can be made up of a single element or compound.

Pure Honey and distilled water are both pure substances.

Ranch and Italian salad dressings are both mixtures.

Aspirin is not an element. Its chemical name is acetylsalicylic acid, abbreviated as ASA.

Soda typically dissolves a chip faster than juice or water due to its carbonation and acidity. The carbonic acid in soda can break down the chip more quickly compared to the less acidic juice or plain water.

aspirin is a popularly known drug. the chemical name of aspirin is acetyl salicylic acid, an organic compound. it is prepared by the reaction of o-hydroxybenzoic acid(salicylic acid) with acetyl chloride or acetic anhydride.

It is a compound because of its constant composition.